Transplantation

UniStain: A unified and organ-aware virtual H&E staining framework for label-free autofluorescence images.

While hematoxylin and eosin (H&E) staining remains the gold standard for pathological diagnosis, its chemical-dependent workflow presents significant limitations, such as time-consuming protocols, hazardous reagent disposal and batch-to-batch variability in stain quality. We present UniStain, a breakthrough virtual staining framework that leverages label-free autofluorescence (AF) imaging and prom...

Machine Learning-Guided Discovery of Sterically Protected High Triplet Exciplex Hosts for Ultra-Bright Green OLEDs.

Machine learning (ML) has been widely used to accelerate the discovery of organic light-emitting diode (OLED) materials, but its application to improving device-level performance has been limited. Here, we develop an ML workflow that explicitly incorporates exciplex-specific design criteria, including exciplex-considered high triplet energy criteria, deep lowest-unoccupied molecular orbital (LUMO)...

Sustainable MXene-based wearable sensor reinforced with microcrystalline cellulose for human motion monitoring in subzero environments with integrated machine learning.

Flexible sensors encounter significant challenges in subzero temperatures, including mechanical fragility, signal instability, and environmental susta...

Decoding Senescence-Driven Heterogeneity in Early-Onset Colorectal Cancer for Prognostic and Therapeutic Stratification.

Early-onset colorectal cancer (EOCRC), diagnosed in patients under 50, is particularly aggressive, yet lacks targeted therapeutic strategies. This stu...

Geroscience insights into difficult-to-treat rheumatoid arthritis: the role of unhealthy aging, comorbidity, and therapeutic complexity.

Difficult-to-treat rheumatoid arthritis (D2T RA) is an emerging challenge in aging populations, where disease persistence and therapeutic failure ofte...

Post-Translational Modification Mediated By Acylation Modification Related Genes Induces Immunosuppression and Immunotherapy Resistance in Head and Neck Squamous Cell Carcinoma.

Acylation modification plays a crucial role in modulating head and neck squamous cell carcinoma (HNSCC) progression, and their specific prognostic imp...

Stage-specific FeS-mediated regulation of Paracoccus denitrificans during carbon consumption by machine learning-assisted comparative proteomics.

Inorganic electron donors improve low C/N wastewater denitrification performance and management. This study used an integrated strategy combining prot...

Integrative analysis of single-cell and bulk transcriptomes reveals metabolic heterogeneity and identifies PFKP as a therapeutic target in cervical cancer.

Cervical cancer (CC) is still a major gynecological tumor among women globally. The heterogeneity landscape and prognostic value of metabolic reprogra...

Tenuigenin ameliorates Alzheimer's disease by targeting MAP2K1: integrated evidence from network pharmacology and experimental validation.

OBJECTIVE: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder primarily characterized by progressive cognitive impairment and synaptic...

Bioinformatic applications in blood group molecular typing.

The application of molecular laboratory methods to predict the expression of red blood cell antigens is well established in today's clinical transfusi...

Biophysics of organoids.

Organoids, 3D in vitro structures derived from embryonic or adult stem cells, offer powerful models for studying tissue patterning, development, morph...

Application of large language and artificial intelligence modeling in the prediction of peer-review outcomes.

OBJECTIVE: The rapid development of artificial intelligence (AI) presents an opportunity to streamline the peer-review process and provide key informa...

Defining weight trajectory after liver transplantation using generative artificial intelligence.

A better understanding of weight trajectories in liver transplant (LT) recipients is essential to improving clinical outcomes. We utilized Generative ...

Exploring Patients' Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial.

OBJECTIVE: The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyr...

Evaluating the Reliability of GPT-4o in Histological Image Interpretation.

Advanced large language models with multimodal capabilities offer potential new applications in medical education. This study evaluated GPT-4o's perfo...

Progress in constitutive modeling of arterial wall tissue mechanics: from theoretical frameworks to clinical application.

Cardiovascular disease (CVD) is a leading cause of mortality worldwide, and the mechanical behavior of arterial wall tissue (AWT) is central to its in...

From mechanism to application: Harnessing oxidative stress signaling for innovative food design.

As a central pathological process in aging and chronic diseases, oxidative stress (OS) stems from redox imbalance and propagates cellular damage throu...

Combining crystal engineering and surface engineering to estimate the structure -functions relationship of Tafamidis solid state forms with the aid of machine learning.

The mutual benefits of surface engineering and crystal engineering led to the discovery of a pharmaceutical cocrystal with balanced biopharmaceutical ...

Cellular and molecular determinants of lymph node metastasis in papillary thyroid carcinoma: Integrated multi-omics profiling and machine learning models.

The mechanisms underlying lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) remain elusive. This study integrated single-cell RNA seque...

Plant-derived angiotensin-converting enzyme regulatory peptides: Potential sources, mechanisms and applications.

Angiotensin-converting enzyme (ACE) is mainly categorized into ACE-1 and ACE-2, both of which play significant roles in human physiological balance an...