Transplantation

Barriers and enablers for publishing results of randomized trials: a cross-sectional survey of principal investigators in sub-Saharan Africa.

OBJECTIVES: To investigate the views and experiences of principal investigators (PIs) based in sub-Saharan Africa (SSA) regarding publication bias of randomised controlled trials (RCTs) and strategies to mitigate it. DESIGN: Cross-sectional online survey, informed by previous reviews and prior surveys on publication bias. The survey consisted of closed-ended items with Likert scales and optional f...

Advanced systems for intraoperative cartilage evaluation and treatment demonstrate early feasibility and a shift towards integrating artificial intelligence: A scoping review.

PURPOSE: To review the current literature evaluating AI and advanced technologies for intraoperative cartilage management. METHODS: A comprehensive search of PubMed, Embase, and Scopus was conducted in March 2026 according to PRISMA guidelines. Eligible studies included cadaveric, in-vivo, or clinical investigations using AI-based or computer navigation systems for real-time intraoperative diagnos...

Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learning.

BACKGROUND: Immunotherapy has shown limited efficacy in a substantial subset of CRC patients, yet the mechanisms underlying therapeutic resistance rem...

Body composition radiomics integrated with machine learning to predict prognosis in advanced NSCLC treated with first-line immunochemotherapy and concurrent radiotherapy.

OBJECTIVE: Adipose tissue is a highly heterogeneous and plastic endocrine and immune organ whose characteristics have been linked to prognosis in NSCL...

Development of a Knowledge Map for Managing Symptoms of Graft-Versus-Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplantation.

BACKGROUND: Graft-versus-host disease (GVHD) remains a critical complication affecting patients undergoing hematopoietic stem cell transplantation (HS...

A four-gene signature for diagnosis of acute kidney injury following kidney transplantation.

Acute kidney injury (AKI) is a common and severe complication following renal transplantation, largely driven by ischemia-reperfusion injury (IRI). Ho...

Computational prediction of TCR cross-reactivity: principles, challenges and translational opportunities.

T-cell receptor (TCR) cross-reactivity, whereby a single TCR recognizes multiple peptide-MHC (pMHC) ligands, is essential for immune surveillance but ...

Donor-Independent Metabolomics Enables Bloodstain Age Determination at Crime Scenes.

Determining when bloodstains were deposited remains an unsolved challenge in forensic science, limiting investigators' ability to reconstruct events a...

Prognostic prediction models for psoriatic arthritis in psoriasis: A systematic review.

BACKGROUND: Psoriatic arthritis is a chronic inflammatory arthropathy that affects up to 22% of individuals with psoriasis. Identifying patients at hi...

Engineered small extracellular vesicles in hematologic malignancies: mechanisms, therapeutic strategies, and translational challenges.

Hematologic malignancies remain among the most challenging cancers to treat due to genetic heterogeneity, clonal evolution, and therapy resistance. Ex...

Stem Cell Therapy for Traumatic Brain Injury: Translational Mechanisms, Biomarkers, and Clinical Trials.

Traumatic brain injury (TBI) is a leading cause of persistent cognitive, motor, and neuropsychiatric impairment, arising from both the initial mechani...

Preclinical Models of Rare Corneal and Ocular Surface Diseases: a Comprehensive Narrative Review.

Rare eye diseases of the cornea and ocular surface (REDs) remain a clinical challenge owing to their low prevalence, heterogeneous presentation, and l...

Multi-Omics Analysis Identifies Paxillin as a Biomarker of Doxorubicin Resistance via Cytoskeletal Remodeling and Immune Exhaustion.

Chemotherapy resistance remains a primary cause of treatment failure in breast cancer, yet the global proteomic landscape driving this phenotype has n...

Assistive communication technologies for individuals with multiple disabilities: an evidence mapping review informing future AI-enabled AAC.

OBJECTIVE: Assistive communication technologies are central to participation for individuals with multiple disabilities. Although artificial intellige...

[Reirradiation: A new therapeutic paradigm in oncology].

Reirradiation (reRT) has become an essential therapeutic option for selected patients with locoregional recurrences, when surgery or systemic therapie...

Effect of chemical treatment on the mechanical and thermal performance of flax fiber reinforced aluminium 6082 laminate: a machine learning-enhanced investigation.

This work examined the role of alkaline and epoxy-based surface chemical treatments on the mechanical and thermal properties of flax fiber reinforced ...

Continuous predictive mortality risk monitoring after allogeneic hematopoietic stem cell transplantation.

Allogeneic hematopoietic stem cell transplantation remains critical for treating high-risk hematological malignancies like leukemia. Despite advances ...

Multifaceted role of histopathology in liver transplantation for hepatocellular carcinoma: A narrative review towards precision prognosis.

Hepatocellular carcinoma is a leading cause of cancer mortality globally. Liver transplantation is considered the best curative treatment for selected...

Immunologic clustering of donor-specific antibodies and clinical outcomes in kidney transplant recipients.

BACKGROUND: Donor-specific antibodies (DSA) against human leukocyte antigens (HLA) are associated with increased immunologic risk in kidney transplant...

Mechanism-Based Multitarget Modeling for Pathway-Level Prediction of PI3K/Akt Signaling Perturbation Induced by Liquid Crystal Monomers.

Liquid crystal monomers (LCMs) are emerging contaminants whose system-level toxicity mechanisms remain poorly understood. Here, we developed a pathway...