Vaccines

Development Of the VAMPCT Score for Predicting Mortality in CKD Patients with COVID-19.

Chronic kidney disease (CKD) patients with coronavirus disease 2019 (COVID-19) are at significant risk of death. However, clinical identification of high-risk individuals remains suboptimal despite the recognition of many pathophysiological and comorbidity-related risk factors. We aim to develop a clinically simple machine learning (ML)-based score to predict acute COVID-19 mortality among CKD pa...

Evaluating sentiment analysis models: A comparative analysis of vaccination tweets during the COVID-19 phase leveraging DistilBERT for enhanced insights.

This study investigates public sentiment toward COVID-19 vaccinations by analyzing Twitter data using advanced machine learning (ML) and natural language processing (NLP) techniques. Recognizing social media as a valuable source for gauging public opinion during health crises, the research aims to inform policies on content moderation and misinformation control.•Comparative Analysis of Embedding T...

Assessing the value of artificial intelligence-based image analysis for pre-operative surgical planning of neck dissections and iENE detection in head and neck cancer patients.

OBJECTIVES: Accurate preoperative detection and analysis of lymph node metastasis (LNM) in head and neck squamous cell carcinoma (HNSCC) is essential ...

CervicalMethDx: a precision DNA methylation test to identify risk of high-grade intraepithelial lesions in cervical cancer screening algorithms.

Cervical cancer is one of the most common cancers in women. Despite progress in prevention and success in early detection through cytologic screening ...

Recent Advances in Applications of Machine Learning in Cervical Cancer Research: A Focus on Prediction Models.

Artificial intelligence (AI) and machine learning (ML) are transforming cervical cancer research and offering advancements in diagnosis, prognosis, sc...

Can ChatGPT Counter Vaccine Hesitancy? An Evaluation of ChatGPT's Responses to Simulated Queries from the General Public.

Vaccines have eradicated deadly diseases, yet vaccine hesitancy persists, leading to reduced uptake. Some individuals, mistrustful of healthcare prov...

Deep learning architectures for influenza dynamics and treatment optimization: a comprehensive review.

As a major worldwide health concern, influenza still requires precise modeling of flu dynamics and efficient treatment approaches. Deep learning archi...

Leveraging pre-vaccination antibody titres across multiple influenza H3N2 variants to forecast the post-vaccination response.

BACKGROUND: Despite decades of research on the influenza virus, we still lack a predictive understanding of how vaccination reshapes each person's ant...

Multi-Omics Analysis of the virulence factors and designing of next-generation multi-epitopes Vaccines against Rickettsia prowazekii: a computer-aided vaccine designing approach.

Rickettsia is a genus of bacteria that are obligate intracellular parasites and are responsible for the febrile diseases known collectively as Rickett...

Messenger Ribonucleic Acid (mRNA)-Based Universal Vaccines: Engineering Broad-Spectrum Immunity Against Future Pandemics.

The rapid emergence and evolution of infectious pathogens, including the COVID-19 pandemic and recurring influenza outbreaks, underscore the need for ...

Unmet needs in autoimmune liver diseases.

Autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis are well-defined autoimmune liver diseases, the pathophysiology ...

Enhancing Label-Free Fluorescence Lifetime Imaging for Intraoperative Tumor Margin Delineation in Head and Neck Cancer using Data-Centric AI.

Precise intraoperative delineation of tumor margin is critical for maximizing resection completeness and minimizing recurrence in head and neck cancer...

Semen HPV and IVF: insights from infection prevalence to embryologic outcomes.

PURPOSE: Human papillomavirus (HPV), the most common sexually transmitted infection, has been proposed as a potential factor in male infertility. This...

Advances of oncolytic vaccinia viruses armed with interleukin in tumor therapy.

Oncolytic vaccinia viruses armed with interleukins represent a promising frontier in tumor therapy. Oncolytic vaccinia viruses express IL-2, IL-10, IL...

Multi-criteria decision making and its application to in silico discovery of vaccine candidates for Toxoplasma gondii.

Vaccine discovery against eukaryotic parasites is not trivial and few exist. Reverse vaccinology is an in silico vaccine discovery approach, designed ...

Polyanhydride-Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single-Injection Self-Boosting Vaccines.

Vaccination remains a critical tool in preventing infectious diseases, yet its effectiveness is undermined by under-immunization, particularly for vac...

SARS-CoV-2: lessons in virus mutation prediction and pandemic preparedness.

The COVID-19 pandemic has prompted an unprecedented global response. In particular, extraordinary efforts have been dedicated toward monitoring and pr...

Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes.

BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted, arthritogenic alphavirus that causes sporadic outbreaks of often debilitating rheumat...

Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy.

Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure t...

Communication about COVID-19 with urban American Indian and Alaska Native peoples: the role of health literacy, trust, and information source.

BACKGROUND: Developing optimal health communication strategies about COVID-19 and vaccines requires an understanding of the health literacy level of p...