AI Medical Compendium Journal:
Biochimica et biophysica acta. Molecular basis of disease

Showing 11 to 17 of 17 articles

Evolutionary artificial intelligence based peptide discoveries for effective Covid-19 therapeutics.

Biochimica et biophysica acta. Molecular basis of disease
An epidemic caused by COVID-19 in China turned into pandemic within a short duration affecting countries worldwide. Researchers and companies around the world are working on all the possible strategies to develop a curative or preventive strategy for...

A machine learning framework to trace tumor tissue-of-origin of 13 types of cancer based on DNA somatic mutation.

Biochimica et biophysica acta. Molecular basis of disease
Carcinoma of unknown primary (CUP), defined as metastatic cancers with unknown cancer origin, occurs in 3-5 per 100 cancer patients in the United States. Heterogeneity and metastasis of cancer brings great difficulties to the follow-up diagnosis and ...

Analysis of gene expression profiles of lung cancer subtypes with machine learning algorithms.

Biochimica et biophysica acta. Molecular basis of disease
Lung cancer is one of the most common cancer types worldwide and causes more than one million deaths annually. Lung adenocarcinoma (AC) and lung squamous cell cancer (SCC) are two major lung cancer subtypes and have different characteristics in sever...

Identification of the functional alteration signatures across different cancer types with support vector machine and feature analysis.

Biochimica et biophysica acta. Molecular basis of disease
Cancers are regarded as malignant proliferations of tumor cells present in many tissues and organs, which can severely curtail the quality of human life. The potential of using plasma DNA for cancer detection has been widely recognized, leading to th...

Identification of human circadian genes based on time course gene expression profiles by using a deep learning method.

Biochimica et biophysica acta. Molecular basis of disease
Circadian genes express periodically in an approximate 24-h period and the identification and study of these genes can provide deep understanding of the circadian control which plays significant roles in human health. Although many circadian gene ide...

Distinguishing three subtypes of hematopoietic cells based on gene expression profiles using a support vector machine.

Biochimica et biophysica acta. Molecular basis of disease
Hematopoiesis is a complicated process involving a series of biological sub-processes that lead to the formation of various blood components. A widely accepted model of early hematopoiesis proceeds from long-term hematopoietic stem cells (LT-HSCs) to...

Identification of genes related to proliferative diabetic retinopathy through RWR algorithm based on protein-protein interaction network.

Biochimica et biophysica acta. Molecular basis of disease
Proliferative diabetic retinopathy (PDR) is one of the most common complications of diabetes and can lead to blindness. Proteomic studies have provided insight into the pathogenesis of PDR and a series of PDR-related genes has been identified but are...