AIMC Topic: Neoplasms, Unknown Primary

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Development of a Predictive Model of Occult Cancer After a Venous Thromboembolism Event Using Machine Learning: The CLOVER Study.

Medicina (Kaunas, Lithuania) Dec 27, 2024
: Venous thromboembolism (VTE) can be the first manifestation of an underlying cancer. This study aimed to develop a predictive model to assess the risk of occult cancer between 30 days and 24 months after a venous thrombotic event using machine lear...
Venous Thromboembolism Spain Neoplasms, Unknown Primary Neoplasms Case-Control Studies ROC Curve Registries Machine Learning Prospective Studies Female Risk Factors Male Middle Aged Risk Assessment Aged Adult Humans
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Image-based deep learning model using DNA methylation data predicts the origin of cancer of unknown primary.

Neoplasia (New York, N.Y.) Jun 28, 2024
Cancer of unknown primary (CUP) is a rare type of metastatic cancer in which the origin of the tumor is unknown. Since the treatment strategy for patients with metastatic tumors depends on knowing the primary site, accurate identification of the orig...
Humans DNA Methylation Algorithms CpG Islands Biomarkers, Tumor Deep Learning Neoplasms, Unknown Primary Image Processing, Computer-Assisted
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Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning.

Nature medicine Apr 16, 2024
Cancer of unknown primary (CUP) site poses diagnostic challenges due to its elusive nature. Many cases of CUP manifest as pleural and peritoneal serous effusions. Leveraging cytological images from 57,220 cases at four tertiary hospitals, we develope...
Humans Female Aged Aged, 80 and over ROC Curve Ascites Cytodiagnosis Neoplasms, Unknown Primary Adult Male Middle Aged Deep Learning
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Identification of Tissue of Origin and Guided Therapeutic Applications in Cancers of Unknown Primary Using Deep Learning and RNA Sequencing (TransCUPtomics).

The Journal of molecular diagnostics : JMD Jul 26, 2021
Cancers of unknown primary (CUP) are metastatic cancers for which the primary tumor is not found despite thorough diagnostic investigations. Multiple molecular assays have been proposed to identify the tissue of origin (TOO) and inform clinical care;...
RNA-Seq Data Accuracy Neoplasms, Unknown Primary Gene Fusion Aged Aged, 80 and over Adult Biomarkers, Tumor Male Middle Aged Transcriptome Deep Learning Humans Prospective Studies Retrospective Studies Female
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AI-based pathology predicts origins for cancers of unknown primary.

Nature May 5, 2021
Cancer of unknown primary (CUP) origin is an enigmatic group of diagnoses in which the primary anatomical site of tumour origin cannot be determined. This poses a considerable challenge, as modern therapeutics are predominantly specific to the primar...
Cohort Studies Workflow Neoplasm Metastasis Neoplasms, Unknown Primary Humans Artificial Intelligence Reproducibility of Results Sensitivity and Specificity Male Computer Simulation Female
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CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence.

EBioMedicine Oct 9, 2020
BACKGROUND: Cancer of unknown primary (CUP), representing approximately 3-5% of all malignancies, is defined as metastatic cancer where a primary site of origin cannot be found despite a standard diagnostic workup. Because knowledge of a patient's pr...
Humans Neural Networks, Computer Artificial Intelligence Machine Learning Neoplasm Metastasis Software Neoplasms, Unknown Primary Computational Biology Databases, Genetic Workflow RNA Algorithms Reproducibility of Results Biomarkers, Tumor Genomics
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A machine learning framework to trace tumor tissue-of-origin of 13 types of cancer based on DNA somatic mutation.

Biochimica et biophysica acta. Molecular basis of disease Aug 7, 2020
Carcinoma of unknown primary (CUP), defined as metastatic cancers with unknown cancer origin, occurs in 3-5 per 100 cancer patients in the United States. Heterogeneity and metastasis of cancer brings great difficulties to the follow-up diagnosis and ...
Mutation Positron-Emission Tomography Neoplasms, Unknown Primary Machine Learning Algorithms Sequence Analysis, DNA DNA
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Transoral robotic surgery for the management of head and neck squamous cell carcinoma of unknown primary.

Acta oto-laryngologica Jun 13, 2015
CONCLUSION: The addition of transoral robotic surgery (TORS) in the diagnostic management of patients classified with head and neck squamous cell carcinoma of unknown primary (SCCUP) is promising and appears to improve detection rates of the primary ...
Neoplasms, Unknown Primary Treatment Outcome Carcinoma, Squamous Cell Humans Squamous Cell Carcinoma of Head and Neck Aged Neoplasm Staging Retrospective Studies Head and Neck Neoplasms Male Tomography, X-Ray Computed Mouth Robotics Middle Aged Female Positron-Emission Tomography Natural Orifice Endoscopic Surgery
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Deep learning-based classifier for carcinoma of unknown primary using methylation quantitative trait loci.

Journal of neuropathology and experimental neurology Feb 1, 2025
Cancer of unknown primary (CUP) constitutes between 2% and 5% of human malignancies and is among the most common causes of cancer death in the United States. Brain metastases are often the first clinical presentation of CUP; despite extensive patholo...
Humans Middle Aged Retrospective Studies Deep Learning DNA Methylation Female Quantitative Trait Loci Aged Neoplasms, Unknown Primary Male
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Artificial Intelligence Estimates the Importance of Baseline Factors in Predicting Response to Anti-PD1 in Metastatic Melanoma.

American journal of clinical oncology Aug 1, 2019
OBJECTIVE: Prognosis of patients with metastatic melanoma has dramatically improved over recent years because of the advent of antibodies targeting programmed cell death protein-1 (PD1). However, the response rate is ~40% and baseline biomarkers for ...
L-Lactate Dehydrogenase Lymphocyte Count Neoplasms, Unknown Primary Retrospective Studies Uveal Neoplasms Female Melanoma Skin Neoplasms Treatment Outcome Humans Neutrophils Neural Networks, Computer Aged Age Factors Forecasting Survival Rate Mucous Membrane Male Programmed Cell Death 1 Receptor Middle Aged
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