European journal of hospital pharmacy : science and practice
Jan 13, 2019
OBJECTIVES: To determine the influence of different buffers, pH and meropenem concentrations on the degradation rates of meropenem in aqueous solution during storage at 32°C, with the aim of developing a formulation suitable for 24-hour infusion in a...
European journal of hospital pharmacy : science and practice
Dec 1, 2018
BACKGROUND: A combination of methylprednisolone sodium succinate and tropisetron hydrochloride is commonly used to treat the nausea and vomiting associated with antineoplastic therapy. The objective of this study was to investigate the stability of t...
European journal of hospital pharmacy : science and practice
Oct 20, 2018
OBJECTIVES: Although levetiracetam presents an easy dosing and tolerability, therapeutic drug monitoring may be recommended in certain situations. Measurement of levetiracetam in serum plasma is commonly done by high performance liquid chromatography...
European journal of hospital pharmacy : science and practice
Sep 18, 2018
OBJECTIVES: To investigate the effect of pH and buffers on the degradation rate of flucloxacillin and to determine if flucloxacillin can be stabilised using a buffered diluent for up to 14 days when stored at 2°C-8°C including a 24-hour infusion peri...
European journal of hospital pharmacy : science and practice
Jul 7, 2018
INTRODUCTION: According to the manufacturers, the diluted solution of etoposide should not exceed 0.4 mg/mL because precipitation may occur. For high doses or for patients requiring fluid restrictions, etoposide phosphate may be an option but shortag...
European journal of hospital pharmacy : science and practice
Apr 26, 2018
BACKGROUND: Intravenous admixtures of dexketoprofen-trometamol and paracetamol are frequently used in clinical practice due to synergism obtained administering both drugs concomitantly. Physicochemical stability of binary admixture containing both dr...
European journal of hospital pharmacy : science and practice
Jan 27, 2018
BACKGROUND AND OBJECTIVE: Mixing different drugs for use in continuous infusion systems is a common practice in palliative care, but analytical study of compatibility and stability is not always available. The objective of this work is to study the s...
European journal of hospital pharmacy : science and practice
Jan 11, 2018
A Caucasian 39-year-old male patient with a poorly-differentiated infiltrating epidermoid penile carcinoma with urethral invasion was diagnosed. The patient received concomitant adjuvant chemotherapy with radiotherapy in the palliative setting, which...
European journal of hospital pharmacy : science and practice
Nov 9, 2017
OBJECTIVES: This study was conducted to investigate the microbial contamination of caffeine citrate 10 mg/mL oral solution (CCOS) during a simulated in-use test in a clinical environment.