International journal of biological sciences
Jul 1, 2024
Renal cell carcinoma (RCC) is frequently accompanied by tumor thrombus in the venous system with an extremely dismal prognosis. The current Tumor Node Metastasis (TNM) stage and Mayo clinical classification do not appropriately identify preference-s...
International journal of biological sciences
Mar 25, 2024
Immunotherapy plays a key role in cancer treatment, however, responses are limited to a small number of patients. The biological basis for the success of immunotherapy is the complex interaction between tumor cells and tumor immune microenvironment (...
International journal of biological sciences
Jun 26, 2023
Targeted therapies in cancer treatment can improve efficacy and reduce adverse effects by altering the tissue exposure of specific biomolecules. However, there are still large number of target proteins in cancer are still undruggable, owing to the f...
International journal of biological sciences
Jan 1, 2022
Immunotherapy has made great progress in hepatocellular carcinoma (HCC), yet there is still a lack of biomarkers for predicting response to it. Cancer stem cells (CSCs) are the primary cause of the tumorigenesis, metastasis, and multi-drug resistance...
International journal of biological sciences
Apr 10, 2021
Artificial intelligence (AI) is being used to aid in various aspects of the COVID-19 crisis, including epidemiology, molecular research and drug development, medical diagnosis and treatment, and socioeconomics. The association of AI and COVID-19 can ...
International journal of biological sciences
Jan 1, 2021
With the continuous development of medical image informatics technology, more and more high-throughput quantitative data could be extracted from digital medical images, which has resulted in a new kind of omics-Radiomics. In recent years, in addition...
International journal of biological sciences
Jan 1, 2020
In the past 20 years, the concept of surgery has undergone profound changes. Surgical practice has shifted from emphasizing the complete elimination of lesions to achieving optimal rehabilitation in patients. Collaborative optimization of surgery con...
International journal of biological sciences
Aug 6, 2019
About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress...
International journal of biological sciences
Jan 1, 2019
In this paper, a method of characteristic extraction and recognition on lung sounds is given. Wavelet de-noised method is adopted to reduce noise of collected lung sounds and extract wavelet characteristic coefficients of the de-noised lung sounds by...
International journal of biological sciences
Sep 7, 2018
N-methyladenosine (mA) is a prevalent RNA methylation modification involved in several biological processes. Hundreds or thousands of mA sites identified from different species using high-throughput experiments provides a rich resource to construct ...