AIMC Topic: Administration, Oral
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Predicting iron absorption from an effervescent iron supplement in obese patients before and after Roux-en-Y gastric bypass: a preliminary study.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Dec 7, 2018
BACKGROUND & AIMS: Oral iron absorption is hampered in obese and bariatric patients, especially after Roux-en-Y gastric bypass (RYGB). As a result, iron deficiency, which is common in both patient groups, can be difficult to treat by oral supplements...
Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach.
Pharmacological reports : PR
Nov 28, 2018
BACKGROUND: Diabetes mellitus is a deadly disorder in human which induce chronic complications. The streptozotocin (STZ)-induced diabetes in rat is the most common animal model of human diabetes. The present study investigated the effects of novel in...
Pharmacokinetic and safety profile of tofacitinib in children with polyarticular course juvenile idiopathic arthritis: results of a phase 1, open-label, multicenter study.
Pediatric rheumatology online journal
Dec 28, 2017
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in pati...
Quantification and pharmacokinetics of alpinetin in rat plasma by UHPLC-MS/MS using protein precipitation coupled with dilution approach to eliminate matrix effects.
Journal of pharmaceutical and biomedical analysis
Dec 27, 2017
Alpinetin, a bioactive flavonoid, has attracted great attention due to its diverse therapeutic effects, namely anti-oxidant, anti-tumor and anti-inflammatory effects with low systemic toxicity. Various determination methods have been developed in qua...
Primary Care Provider Perceptions and Practices Regarding Dosing Units for Oral Liquid Medications.
Academic pediatrics
Dec 18, 2017
INTRODUCTION: To prevent errors, health care professional and safety organizations recommend using milliliters (mL) alone for oral liquid medication dosing instructions and devices. In 2018, for federal incentives under the Quality Payment Program, o...
Female
Adult
Male
Middle Aged
Surveys and Questionnaires
Humans
Electronic Health Records
Nurse Practitioners
Pediatricians
Physicians, Family
Drug Prescriptions
Attitude of Health Personnel
Electronic Prescribing
Pharmaceutical Preparations
Internal Medicine
Administration, Oral
Medication Errors
Physicians, Primary Care
New, Immunomodulatory, Oral Nutrition Formula for Use Prior to Surgery in Patients With Head and Neck Cancer: An Exploratory Study.
JPEN. Journal of parenteral and enteral nutrition
Dec 12, 2017
BACKGROUND: The perioperative use of immunomodulatory nutrition formulas in patients with head and neck cancer reduces the number of postoperative infections and the length of hospital stay.
Deep Learning Based Regression and Multiclass Models for Acute Oral Toxicity Prediction with Automatic Chemical Feature Extraction.
Journal of chemical information and modeling
Oct 27, 2017
Median lethal death, LD, is a general indicator of compound acute oral toxicity (AOT). Various in silico methods were developed for AOT prediction to reduce costs and time. In this study, we developed an improved molecular graph encoding convolutiona...
Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat.
Journal of food and drug analysis
Sep 22, 2017
Tangeretin, 4',5,6,7,8-pentamethoxyflavone, is one of the major polymethoxyflavones (PMFs) existing in citrus fruits, particularly in the peels of sweet oranges and mandarins. Tangeretin has been reported to possess several beneficial bioactivities i...
Detection of lithospermate B in rat plasma at the nanogram level by LC/MS in multi reaction monitoring mode.
Journal of food and drug analysis
Jul 8, 2017
Low bioavailability and high binding affinity to plasma proteins led to the difficulty for the quantitative detection of lithospermate B (LSB) in plasma. This study aimed to develop a protocol for detecting LSB in plasma. A method was employed to qua...
Intravenous Chlorothiazide Versus Enteral Metolazone to Augment Loop Diuretic Therapy in the Intensive Care Unit.
The Annals of pharmacotherapy
Dec 16, 2016
BACKGROUND: In cases of loop diuretic resistance in the intensive care unit (ICU), recommendations for a specific second-line thiazide agent are lacking.
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