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Administration, Oral

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Levels and effectiveness of oral retinol supplementation in VLBW preterm infants.

International journal of immunopathology and pharmacology 30897987
Retinol palmitate oral administration is convenient, but it is difficult to assess/monitor its nutritional status in preterm infants and literature is controversial about the administration route and the effectiveness of vitamin A supplementation. We...
Administration, Oral Dietary Supplements Female Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature Male Nutritional Status Vitamin A
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Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach.

Pharmacological reports : PR 30807980
BACKGROUND: Diabetes mellitus is a deadly disorder in human which induce chronic complications. The streptozotocin (STZ)-induced diabetes in rat is the most common animal model of human diabetes. The present study investigated the effects of novel in...
Administration, Oral Animals Blood Glucose Diabetes Mellitus, Experimental Dose-Response Relationship, Drug Female Humans Hypoglycemic Agents Indolizines Inhibitory Concentration 50 Male Rats Rats, Wistar Streptozocin
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Predicting iron absorption from an effervescent iron supplement in obese patients before and after Roux-en-Y gastric bypass: a preliminary study.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 30732902
BACKGROUND & AIMS: Oral iron absorption is hampered in obese and bariatric patients, especially after Roux-en-Y gastric bypass (RYGB). As a result, iron deficiency, which is common in both patient groups, can be difficult to treat by oral supplements...
Absorption, Physiological Administration, Oral Adult Dietary Supplements Female Ferrous Compounds Gastric Bypass Humans Male Middle Aged Obesity, Morbid Tablets
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PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.

Acta poloniae pharmaceutica 29624254
Single centered crossover, two cycles volunteer study was performed on 12 healthy male volunteers. Both reference and test, immediate release nimesulide formulation was given in a randomized manner with a washout period of 15 days and 5 mL of blood s...
Administration, Oral Anti-Inflammatory Agents, Non-Steroidal Area Under Curve Chromatography, High Pressure Liquid Cross-Over Studies Half-Life Healthy Volunteers Humans Male Metabolic Clearance Rate Models, Biological Pakistan Sulfonamides Tablets Therapeutic Equivalency Young Adult
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Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat.

Journal of food and drug analysis 29567257
Tangeretin, 4',5,6,7,8-pentamethoxyflavone, is one of the major polymethoxyflavones (PMFs) existing in citrus fruits, particularly in the peels of sweet oranges and mandarins. Tangeretin has been reported to possess several beneficial bioactivities i...
Administration, Oral Animals Biological Availability Citrus Feces Flavones Fruit Gastrointestinal Tract Liver Male Plant Extracts Rats Rats, Sprague-Dawley Tissue Distribution
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Enhancing Acute Oral Toxicity Predictions by using Consensus Modeling and Algebraic Form-Based 0D-to-2D Molecular Encodes.

Chemical research in toxicology 31066547
Quantitative structure-activity relationships (QSAR) are introduced to predict acute oral toxicity (AOT), by using the QuBiLS-MAS (acronym for quadratic, bilinear and N-Linear maps based on graph-theoretic electronic-density matrices and atomic weigh...
Administration, Oral Animals Cluster Analysis Humans Quantitative Structure-Activity Relationship Support Vector Machine Toxicity Tests, Acute
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Robotically handled whole-tissue culture system for the screening of oral drug formulations.

Nature biomedical engineering 32341538
Monolayers of cancer-derived cell lines are widely used in the modelling of the gastrointestinal (GI) absorption of drugs and in oral drug development. However, they do not generally predict drug absorption in vivo. Here, we report a robotically hand...
Administration, Oral Animals Biological Transport Caco-2 Cells Drug Compounding Drug Evaluation, Preclinical Humans Intestinal Absorption Jejunum Oxytocin Permeability Reproducibility of Results Robotics Swine Tissue Culture Techniques User-Computer Interface
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New artificial intelligence prediction model using serial prothrombin time international normalized ratio measurements in atrial fibrillation patients on vitamin K antagonists: GARFIELD-AF.

European heart journal. Cardiovascular pharmacotherapy 31821482
AIMS: Most clinical risk stratification models are based on measurement at a single time-point rather than serial measurements. Artificial intelligence (AI) is able to predict one-dimensional outcomes from multi-dimensional datasets. Using data from ...
Administration, Oral Aged Aged, 80 and over Anticoagulants Atrial Fibrillation Blood Coagulation Databases, Factual Drug Monitoring Drug Therapy, Computer-Assisted Female Hemorrhage Humans International Normalized Ratio Male Neural Networks, Computer Predictive Value of Tests Prospective Studies Prothrombin Time Registries Reproducibility of Results Risk Assessment Risk Factors Stroke Time Factors Treatment Outcome Vitamin K
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An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation design.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 33301864
Drugs in solid dispersion (SD) take advantage of fast and extended dissolution, thus attains a higher bioavailability than the crystal form. However, current development of SD relies on a random large-scale formulation screening method with low effic...
Administration, Oral Biological Availability Data Science Datasets as Topic Drug Design Drug Liberation Intestinal Absorption Machine Learning Models, Biological Molecular Dynamics Simulation Solubility
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Prediction of Oral Acute Toxicity of Organophosphates Using QSAR Methods.

Current computer-aided drug design 31880265
AIMS: Prediction of oral acute toxicity of organophosphates using QSAR methods.
Administration, Oral Algorithms Lethal Dose 50 Linear Models Models, Molecular Neural Networks, Computer Organophosphates Pesticides Quantitative Structure-Activity Relationship Reproducibility of Results Toxicity Tests, Acute
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