AIMC Topic: Algorithms

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Deep learning for cellular image analysis.

Nature methods
Recent advances in computer vision and machine learning underpin a collection of algorithms with an impressive ability to decipher the content of images. These deep learning algorithms are being applied to biological images and are transforming the a...

Spatiotemporal discrimination in attractor networks with short-term synaptic plasticity.

Journal of computational neuroscience
We demonstrate that a randomly connected attractor network with dynamic synapses can discriminate between similar sequences containing multiple stimuli suggesting such networks provide a general basis for neural computations in the brain. The network...

Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk.

Nature genetics
We address the challenge of detecting the contribution of noncoding mutations to disease with a deep-learning-based framework that predicts the specific regulatory effects and the deleterious impact of genetic variants. Applying this framework to 1,7...

Soft-sensing method based on FDLS-SVM in marine alkaline protease fermentation process.

Preparative biochemistry & biotechnology
To overcome the problem that soft-sensing model cannot be updated with the bioprocess changes, this article proposed a soft-sensing modeling method which combined fuzzy c-means clustering (FCM) algorithm with least squares support vector machine theo...

An empirical evaluation of deep learning for ICD-9 code assignment using MIMIC-III clinical notes.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Code assignment is of paramount importance in many levels in modern hospitals, from ensuring accurate billing process to creating a valid record of patient care history. However, the coding process is tedious and subjective,...

Detecting adverse drug reactions in discharge summaries of electronic medical records using Readpeer.

International journal of medical informatics
BACKGROUND: Hospital discharge summaries offer a potentially rich resource to enhance pharmacovigilance efforts to evaluate drug safety in real-world clinical practice. However, it is infeasible for experts to read through all discharge summaries to ...

Protecting the Privacy of Cancer Patients Using Fuzzy Association Rule Hiding.

Asian Pacific journal of cancer prevention : APJCP
Objective: Privacy protection in the medical field means the protection of individuals from being associated with undesirable conditions, diagnoses or treatments (Sensitive Attributes). The problem of knowledge discovery from health care data by appl...

Lessons from Two Design-Build-Test-Learn Cycles of Dodecanol Production in Escherichia coli Aided by Machine Learning.

ACS synthetic biology
The Design-Build-Test-Learn (DBTL) cycle, facilitated by exponentially improving capabilities in synthetic biology, is an increasingly adopted metabolic engineering framework that represents a more systematic and efficient approach to strain developm...

Chronic wound assessment and infection detection method.

BMC medical informatics and decision making
BACKGROUND: Numerous patients suffer from chronic wounds and wound infections nowadays. Until now, the care for wounds after surgery still remain a tedious and challenging work for the medical personnel and patients. As a result, with the help of the...

Local online learning in recurrent networks with random feedback.

eLife
Recurrent neural networks (RNNs) enable the production and processing of time-dependent signals such as those involved in movement or working memory. Classic gradient-based algorithms for training RNNs have been available for decades, but are inconsi...