AIMC Topic: Animals

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Tissue Clutter Filtering Methods in Ultrasound Localization Microscopy Based on Complex-Valued Networks and Knowledge Distillation.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Ultrasound localization microscopy (ULM) is a blood flow imaging technique that utilizes micrometer-sized microbubbles (MBs) as contrast agents to achieve high-resolution microvessel reconstruction through precise localization and tracking of MBs. Th...

Waveform-Specific Performance of Deep Learning-Based Super-Resolution for Ultrasound Contrast Imaging.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Resolving arterial flows is essential for understanding cardiovascular pathologies, improving diagnosis, and monitoring patient condition. Ultrasound contrast imaging uses microbubbles to enhance the scattering of the blood pool, allowing for real-ti...

Transcriptomic Biomarkers in Blood Indicative of the Administration of Recombinant Human Erythropoietin to Thoroughbred Horses.

Drug testing and analysis
Erythropoiesis-stimulating agents (ESAs) continue to be a significant threat to the integrity of human and equine sports. Besides conventional direct testing, monitoring the biomarkers associated with the effects of ESAs may provide a complementary a...

A novel approach for calculating food safety models and health risk assessments of potentially toxic elements (PTEs) in cow milk.

Food chemistry
This study introduces the Milk Quality Index (MQI), a novel metric for assessing milk quality that utilizes machine learning to enhance predictive accuracy. Lead (Pb) levels (318 ± 185 mg/kg) exceeded safety limits, with chromium (Cr), aluminum (Al),...

Bioactive components of Jiedu Sangen decoction against colorectal cancer: A novel and comprehensive research strategy for natural drug development.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Jiedu Sangen Decoction (JSD) is widely used in the treatment of colorectal cancer (CRC) patients in southern China due to its good clinical efficacy, but the effective active ingredients are still unknown.

PLGA-based long-acting injectable (LAI) formulations.

Journal of controlled release : official journal of the Controlled Release Society
Long-acting injectable (LAI) formulations, which deliver drugs over weeks or months, have been in use for more than three decades. Most clinically approved LAI products are formulated using poly(lactide-co-glycolide) (PLGA) polymers. Historically, th...

Deconvolution of cell types and states in spatial multiomics utilizing TACIT.

Nature communications
Identifying cell types and states remains a time-consuming, error-prone challenge for spatial biology. While deep learning increasingly plays a role, it is difficult to generalize due to variability at the level of cells, neighborhoods, and niches in...

Transfer learning of multicellular organization via single-cell and spatial transcriptomics.

PLoS computational biology
Biological tissues exhibit complex gene expression and multicellular patterns that are valuable to dissect. Single-cell RNA sequencing (scRNA-seq) provides full coverages of genes, but lacks spatial information, whereas spatial transcriptomics (ST) m...

Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling.

Drug design, development and therapy
PURPOSE: To determine whether Gui-Pi-Tang (GPT) has protective effects on skeletal muscle and cardiac muscle in aged mice.

SagMSI: A graph convolutional network framework for precise spatial segmentation in mass spectrometry imaging.

Analytica chimica acta
BACKGROUND: Mass Spectrometry Imaging (MSI) is a label-free imaging technique used in spatial metabolomics to explore the distribution of various metabolites within biological tissues. Spatial segmentation plays a crucial role in the biochemical inte...