Disgust, a primary negative emotion, plays a vital role in protecting organisms from intoxication and infection. In rodents, this emotion has been quantified by measuring the specific reactions elicited by exposure to unpleasant tastes. These reactio...
Journal of the American Chemical Society
May 21, 2025
Exploring the time-resolved dynamics of neurochemicals is essential for deciphering neuronal functions, intercellular communication, and neurophysiological or pathological mechanisms. However, the complex interplay among neurochemicals between neuroc...
The arginine dihydrolase pathway (arc operon) provides a metabolic niche by transforming arginine into metabolic byproducts. We investigate the role of the arc operon in probiotic Escherichia coli Nissle 1917 on human gut community assembly and healt...
International journal of molecular sciences
May 20, 2025
Centrilobular hepatocyte hypertrophy is frequently observed in animal studies for chemical safety assessment. Although its toxicological significance and precise mechanism remain unknown, it is considered an adaptive response resulting from the induc...
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
May 20, 2025
OBJECTIVES: To explore the association of the expression of WW domain-containing ubiquitin E3 ligase 1 (WWP1) with immune infiltration in tumor microenvironment (TME) of ovarian cancer.
Miniaturized accelerometers incorporated in pacing leads attached directly onto the heart provide a means for continuous monitoring of cardiac function. Several functional accelerometer indices first require detection of valve events. We previously d...
Meat quality plays a significant role in the consumers' health condition; hence, the constant pursuit for techniques capable of objective and accurate quality assessment by the meat industry. Multispectral imaging and electronic noses are valuable te...
Long-term analysis of animal behavior has been limited by reliance on real-time sensors or manual scoring. Existing machine learning tools can automate analysis but often fail under variable conditions or ignore temporal dynamics. We developed a scal...
Previous studies reported that opioids depress breathing by inhibiting respiratory neural networks in the brainstem. The effects of opioids on sensory inputs regulating breathing are less studied. This study examined the effects of fentanyl and sufen...
Machine learning (ML) is increasingly valuable for predicting molecular properties and toxicity in drug discovery. However, toxicity-related end points have always been challenging to evaluate experimentally with respect to translation due to the re...
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