AIMC Topic: Anti-Retroviral Agents
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Predicting antiretroviral therapy adherence status of adult HIV-positive patients using machine-learning Northwest, Ethiopia, 2025.
BMC medical informatics and decision making
Jul 10, 2025
BACKGROUND: Adherence with Anti-Retroviral Therapy (ART) reduces viral load, as well as HIV-related morbidity and mortality. Despite the expanded availability of ART, non-adherence remains a series problem, leads increased viral load, a decline CD4 c...
Using machine learning to predict poor adherence to antiretroviral therapy among adolescents with HIV in low resource settings.
AIDS (London, England)
Feb 24, 2025
OBJECTIVES: Achieving optimal adherence to antiretroviral therapy (ART) and viral suppression is still insufficient for attaining the UNAIDS 95-95-95 target of 2030, especially among adolescents with HIV (AWHIV). This study sought to develop a model ...
A graph neural network-based model with out-of-distribution robustness for enhancing antiretroviral therapy outcome prediction for HIV-1.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Jan 10, 2025
Predicting the outcome of antiretroviral therapies (ART) for HIV-1 is a pressing clinical challenge, especially when the ART includes drugs with limited effectiveness data. This scarcity of data can arise either due to the introduction of a new drug ...
Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy.
eLife
Sep 9, 2024
Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure. Here, we applied machine learning (ML) approaches to cross-...
Optimizing removal of antiretroviral drugs from tertiary wastewater using chlorination and AI-based prediction with response surface methodology.
The Science of the total environment
May 3, 2024
Chemical and pharmaceutical chemicals found in water sources create substantial risks to human health and the environment. The presence of pharmaceutical contaminants in water can cause antibiotic resistance development, toxicity to aquatic organisms...
antibacterial activity of antiretroviral drugs on key commensal bacteria from the human microbiota.
Frontiers in cellular and infection microbiology
Jan 8, 2024
INTRODUCTION: Antiretroviral therapy has improved life expectancy in HIV-infected patients. However, people living with HIV under antiretroviral therapy are at higher risks of developing chronic complications and acquiring multidrug resistant bacteri...
Evaluation of the pharmacokinetic drug-drug interaction between the antiretroviral agents fostemsavir and maraviroc: a single-sequence crossover study in healthy participants.
HIV research & clinical practice
Mar 14, 2022
BACKGROUND: Fostemsavir is an oral prodrug of temsavir, a first-in-class attachment inhibitor that binds HIV-1 gp120, preventing initial HIV attachment and entry into host immune cells.
Drug Resistance Prediction Using Deep Learning Techniques on HIV-1 Sequence Data.
Viruses
May 19, 2020
The fast replication rate and lack of repair mechanisms of human immunodeficiency virus (HIV) contribute to its high mutation frequency, with some mutations resulting in the evolution of resistance to antiretroviral therapies (ART). As such, studying...
Alendronate/Vitamin D for attenuating bone mineral density loss during antiretroviral initiation: a pilot randomized controlled trial.
HIV research & clinical practice
Feb 27, 2020
Antiretroviral therapy (ART) initiation is associated with decreases in bone mineral density (BMD). To plan for a larger trial, we sought to obtain preliminary estimates for the difference in the change in BMD at 48 weeks achieved with 24 weeks of p...
Vitamin D insufficiency is associated with subclinical atherosclerosis in HIV-1-infected patients on combination antiretroviral therapy.
HIV research & clinical practice
Feb 17, 2020
Vitamin D insufficiency has been associated with faster progression of atherosclerosis and increased cardiovascular disease risk, but limited data are available in HIV-infected people. So, we examined potential correlation between vitamin D status a...
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