AIMC Topic: Antiretroviral Therapy, Highly Active

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Predicting the immunological nonresponse to antiretroviral therapy in people living with HIV: a machine learning-based multicenter large-scale study.

Frontiers in cellular and infection microbiology Mar 11, 2025
BACKGROUND: Although highly active antiretroviral therapy (HAART) has greatly enhanced the prognosis for people living with HIV (PLWH), some individuals fail to achieve adequate immune reconstitution, known as immunological nonresponse (INR), which i...
Humans Machine Learning Prognosis Female HIV Infections Anti-HIV Agents ROC Curve CD4 Lymphocyte Count Antiretroviral Therapy, Highly Active Adult Male Middle Aged China
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Random forest machine learning algorithm predicts virologic outcomes among HIV infected adults in Lausanne, Switzerland using electronically monitored combined antiretroviral treatment adherence.

AIDS care Apr 8, 2020
Machine Learning (ML) can improve the analysis of complex and interrelated factors that place adherent people at risk of viral rebound. Our aim was to build ML model to predict RNA viral rebound from medication adherence and clinical data. Patients w...
Assessment of Medication Adherence Retrospective Studies Female Treatment Outcome Adult Anti-HIV Agents Humans Switzerland Male Cohort Studies Machine Learning CD4 Lymphocyte Count Medication Adherence HIV Infections Algorithms Antiretroviral Therapy, Highly Active Viral Load
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Characterization of low level viraemia in HIV-infected patients receiving boosted protease inhibitor-based antiretroviral regimens.

HIV research & clinical practice Jan 30, 2020
To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months. Samples for next generation sequenc...
United Kingdom Drug Resistance, Multiple, Viral Humans HIV Protease Female Viral Load Adult HIV Protease Inhibitors Middle Aged Mutation Male HIV Infections gag Gene Products, Human Immunodeficiency Virus Viremia Anti-Retroviral Agents Antiretroviral Therapy, Highly Active HIV-1 High-Throughput Nucleotide Sequencing
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A comparative study of logistic regression based machine learning techniques for prediction of early virological suppression in antiretroviral initiating HIV patients.

BMC medical informatics and decision making Sep 4, 2018
BACKGROUND: Treatment with effective antiretroviral therapy (ART) lowers morbidity and mortality among HIV positive individuals. Effective highly active antiretroviral therapy (HAART) should lead to undetectable viral load within 6 months of initiati...
Male HIV Infections Viral Load Anti-HIV Agents Cohort Studies Humans Machine Learning Female Adult Antiretroviral Therapy, Highly Active Logistic Models Treatment Outcome Predictive Value of Tests CD4 Lymphocyte Count
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Paraconsistents artificial neural networks applied to the study of mutational patterns of the F subtype of the viral strains of HIV-1 to antiretroviral therapy.

Anais da Academia Brasileira de Ciencias Mar 4, 2016
The high variability of HIV-1 as well as the lack of efficient repair mechanisms during the stages of viral replication, contribute to the rapid emergence of HIV-1 strains resistant to antiretroviral drugs. The selective pressure exerted by the drug ...
Antiretroviral Therapy, Highly Active HIV-1 Drug Resistance, Viral Virus Replication Humans Neural Networks, Computer Mutation
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High frequency of neurosyphilis in HIV-positive patients diagnosed with early syphilis.

HIV medicine Sep 10, 2015
BACKGROUND: Syphilis is an infection frequently seen with HIV, and European guidelines on the management of syphilis suggest that HIV-infected patients may have an increased risk of early neurological involvement, sometimes asymptomatic. Recent study...
Syphilis Antiretroviral Therapy, Highly Active HIV-1 Neurosyphilis Humans Risk Factors Young Adult Viral Load Adult Male Anti-HIV Agents CD4 Lymphocyte Count HIV Infections
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Ensemble learning of inverse probability weights for marginal structural modeling in large observational datasets.

Statistics in medicine Oct 15, 2014
Inverse probability weights used to fit marginal structural models are typically estimated using logistic regression. However, a data-adaptive procedure may be able to better exploit information available in measured covariates. By combining predicti...
Confounding Factors, Epidemiologic Logistic Models Models, Statistical Data Interpretation, Statistical Bias Confidence Intervals Spain Mortality Humans Antiretroviral Therapy, Highly Active Probability Machine Learning Computer Simulation HIV Infections
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[Virological evolution of patients with HIV infection that start antiretroviral therapy with a very high baseline viral load].

Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia Dec 1, 2021
BACKGROUND: The degree of viral suppression in HIV patients who start antiretroviral therapy (ART) with very high viral loads (CV) is unknown.
Anti-HIV Agents CD4 Lymphocyte Count Humans Antiretroviral Therapy, Highly Active Retrospective Studies Serologic Tests HIV Infections Viral Load
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Real World Patient-reported Outcomes in HIV-infected Adults Switching to EVIPLERA®, Because of a Previous Intolerance to cART. PRO-STR Study.

Current HIV research Jan 1, 2018
BACKGROUND: To investigate the impact of switching from stable Combined Antiretroviral Therapy (cART) to single-tablet regimen (RPV/FTC/TDF=EVIPLERA® /COMPLERA®) on patient- reported outcomes in HIV-infected adults who cannot tolerate previous cART, ...
CD4 Lymphocyte Count Antiretroviral Therapy, Highly Active Patient Reported Outcome Measures Drug Substitution Viral Load Anti-HIV Agents Treatment Outcome Drug Combinations Adult Humans Male Middle Aged Prospective Studies Quality of Life Female HIV Infections
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Efficacy of eculizumab in an adult patient with HIV-associated hemolytic uremic syndrome: A case report.

Medicine Dec 1, 2017
INTRODUCTION: Hemolytic uremic syndrome (HUS) in Human Immunodeficiency Virus (HIV)-positive patients has become a rare cause of kidney injury since the era of highly active antiretroviral therapy (HAART). Plasma exchange and antiretroviral therapy w...
Humans Acute Kidney Injury Female Middle Aged HIV Infections Treatment Outcome Kidney Function Tests Risk Assessment Immunohistochemistry Antibodies, Monoclonal, Humanized Renal Dialysis Biopsy, Needle Follow-Up Studies Hemolytic-Uremic Syndrome Antibodies, Monoclonal Plasma Exchange Antiretroviral Therapy, Highly Active
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