AIMC Topic: Autism Spectrum Disorder

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Machine learning of clinical phenotypes facilitates autism screening and identifies novel subgroups with distinct transcriptomic profiles.

Scientific reports
Autism spectrum disorder (ASD) presents significant challenges in diagnosis and intervention due to its diverse clinical manifestations and underlying biological complexity. This study explored machine learning approaches to enhance ASD screening acc...

Sulforaphane protects developing neural networks from VPA-induced synaptic alterations.

Molecular psychiatry
Prenatal brain development is particularly sensitive to chemicals that can disrupt synapse formation and cause neurodevelopmental disorders. In most cases, such chemicals increase cellular oxidative stress. For example, prenatal exposure to the anti-...

Random forest and Shapley Additive exPlanations predict oxytocin targeted effects on brain functional networks involved in salience and sensorimotor processing, in a randomized clinical trial in autism.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Intranasal oxytocin (IN-OXT) has shown some promises in rescuing social deficits in autism spectrum disorder (ASD) as well as some inconsistencies in long-term trials. We conducted a target engagement study to study the precise effects of different d...

Using machine learning to identify features associated with different types of self-injurious behaviors in autistic youth.

Psychological medicine
BACKGROUND: Self-injurious behaviors (SIB) are common in autistic people. SIB is mainly studied as a broad category, rather than by specific SIB types. We aimed to determine associations of distinct SIB types with common psychiatric, emotional, medic...

Automated Autism Assessment With Multimodal Data and Ensemble Learning: A Scalable and Consistent Robot-Enhanced Therapy Framework.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Navigating the complexities of Autism Spectrum Disorder (ASD) diagnosis and intervention requires a nuanced approach that addresses both the inherent variability in therapeutic practices and the imperative for scalable solutions. This paper presents ...

Two-tier nature inspired optimization-driven ensemble of deep learning models for effective autism spectrum disorder diagnosis in disabled persons.

Scientific reports
Autism spectrum disorder (ASD) includes a varied set of neuropsychiatric illnesses. This disorder is described by a definite grade of loss in social communication, academic functioning, personal contact, and limited and repetitive behaviours. Individ...

Capsule DenseNet++: Enhanced autism detection framework with deep learning and reinforcement learning-based lifestyle recommendation.

Computers in biology and medicine
Autism Spectrum Disorder (ASD) is a complex neurological condition that impairs the ability to interact, communicate, and behave. It is becoming increasingly prevalent worldwide, with an increase in the number of young children diagnosed with ASD in ...

Heterogeneous Graph Representation Learning Framework for Resting-State Functional Connectivity Analysis.

IEEE transactions on medical imaging
Brain functional connectivity analysis is important for understanding brain development and brain disorders. Recent studies have suggested that the variations of functional connectivity among multiple subnetworks are closely related to the developmen...

Optimized attention-enhanced U-Net for autism detection and region localization in MRI.

Psychiatry research. Neuroimaging
Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects a child's cognitive and social skills, often diagnosed only after symptoms appear around age 2. Leveraging MRI for early ASD detection can improve intervention outcomes. Th...

Semi-Automated Multi-Label Classification of Autistic Mannerisms by Machine Learning on Post Hoc Skeletal Tracking.

Autism research : official journal of the International Society for Autism Research
Mannerisms describe repetitive or unconventional body movements like arm flapping. These movements are early markers of restricted and repetitive behaviors (RRBs) in autism spectrum disorder (ASD). However, assessing mannerisms reliably is challengin...