IEEE journal of biomedical and health informatics
Jan 17, 2022
The combination of Raman spectroscopy and deep learning technology provides an automatic, rapid, and accurate scheme for the clinical diagnosis of pathogenic bacteria. However, the accuracy of existing deep learning methods is still limited because o...
Accurate and rapid identification of infectious bacteria is important in medicine. Raman microspectroscopy holds great promise in performing label-free identification at the single-cell level. However, due to the naturally weak Raman signal, it is a ...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jan 5, 2022
Previously, we successfully realized the identification of a single species of bacteria based on the multi-wavelength transmission spectrum of bacteria. The current research is focused on realizing the spectral analysis of mixed bacteria. Principal c...
Operon prediction in prokaryotes is critical not only for understanding the regulation of endogenous gene expression, but also for exogenous targeting of genes using newly developed tools such as CRISPR-based gene modulation. A number of methods have...
Bacterial small regulatory RNAs (sRNAs) are key regulators of gene expression in many processes related to adaptive responses. A multitude of sRNAs have been identified in many bacterial species; however, their function has yet to be elucidated. A ke...
Clinical metagenomics is a powerful diagnostic tool, as it offers an open view into all DNA in a patient's sample. This allows the detection of pathogens that would slip through the cracks of classical specific assays. However, due to this unspecific...
Fighting with the infection is one of the most challenging and costly burdens of the healthcare system. Several types of antibiotics and antibacterial agents have been designed and used in combating this dilemma. Nevertheless, the overuse of drugs an...
Mathematical biosciences and engineering : MBE
Nov 18, 2021
In this paper, a novel bio-inspired trajectory planning method is proposed for robotic systems based on an improved bacteria foraging optimization algorithm (IBFOA) and an improved intrinsic Tau jerk (named Tau-J*) guidance strategy. Besides, the ada...
Tape measure (TM) proteins are essential for the formation of long-tailed phages. TM protein assembly into tails requires the action of tail assembly chaperones (TACs). TACs (e.g. gpG and gpT of E. coli phage lambda) are usually produced in a short (...
The enrichment of polyhydroxyalkanoates (PHA) accumulating bacteria (PAB) in mixed microbial cultures (MMC) is extremely difficult to be predicted and optimized. Here we demonstrate that mechanistic and deep learning models can be integrated innovati...