AIMC Topic: Bacterial Proteins

Clear Filters Showing 11 to 20 of 202 articles

AI-powered programmable wetting-delamination μPAD for point-of-care food safety detection.

Biosensors & bioelectronics
The widespread use of pesticides and genetically modified (GM) crops has greatly improved agricultural productivity and food security. However, excessive pesticide application and the presence of exogenous proteins from GM crops pose significant risk...

High-content high-resolution microscopy and deep learning-assisted analysis reveals host and bacterial heterogeneity during infection.

eLife
is a Gram-negative bacterial pathogen and causative agent of bacillary dysentery. is closely related to but harbours a virulence plasmid that encodes a type III secretion system (T3SS) required for host cell invasion. Widely recognised as a paradi...

Deep-Learning-Guided Mining and Clustering of Remote Amino Acid Residues for the Simultaneous Engineering of the Catalytic Activity and Thermostability of a Processive Endoglucanase.

ACS synthetic biology
Processive endoglucanases, which possess both endo- and exoglucanase activities, are considered highly promising catalysts in cellulose degradation. In this study, we employed multiple deep learning models, including MutCompute, DeepSequence, and ESM...

Machine-Learning-Assisted CRISPR/Cas12a Biosensors for Monitoring Organophosphorus Pesticide Degradation.

Analytical chemistry
Owing to the severe environmental and health issues posed by organophosphorus pesticides (OPs), a dual-enzyme cascade biosensing platform based on manganese dioxide (MnO) and CRISPR/Cas12a was developed in this study. Smartphones were innovatively in...

Unravelling mutation patterns in Extended-Spectrum β-Lactamases for precision drug design against AMR in Enterobacteriaceae.

Molecular genetics and genomics : MGG
Antimicrobial resistance (AMR) presents a critical global challenge, causing over 1.27 million deaths annually, with projections reaching 10 million by 2050. Among the most concerning contributors are Enterobacteriaceae, particularly Escherichia coli...

The potential to improve Lyme disease diagnostics through quantification of immunoglobulin class switching patterns.

Journal of clinical microbiology
N. Nair, A. Marques , E. J. Horn, G. Brown et al., J Clin Microbiol 63:e0034725, 2025, https://doi.org/10.1128/jcm.00347-25 present data to demonstrate that infection by , the primary causative agent of Lyme disease in the USA, leads to immunoglobuli...

Field-oriented assessment of bovine tuberculosis in Tunisian cattle: IDR, PCR and serological test prediction based on AI approaches.

World journal of microbiology & biotechnology
Bovine tuberculosis (bTB), caused by Mycobacterium bovis (M. bovis), remains a major zoonotic and economically burdensome disease worldwide. In Tunisia, where bTB has remained present for many years, Efforts to eliminate the disease have been slowed ...

De novo design of potent inhibitors of clostridial family toxins.

Proceedings of the National Academy of Sciences of the United States of America
remains a leading cause of hospital-acquired infections, with its primary virulence factor, toxin B (TcdB), responsible for severe colitis and recurrent disease. The closely related toxin, TcsL, from , causes a rarer but often fatal toxic shock synd...

Prediction of protein structural changes mediated by NS-SNPs in antibiotic resistance determinants in Streptococcus pneumoniae.

Archives of microbiology
Streptococcus pneumoniae (S. pneumoniae) is a gram-positive bacterium, which is a human pathogen that colonises the human nasopharyngeal region. The evolution of its resistance to many antibiotics has become a major clinical and public health problem...