AIMC Topic: Klebsiella

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Cloning, Characterization, and Computer-Aided Evolution of a Thermostable Laccase of the DUF152 Family From Klebsiella michiganensis.

Proteins Feb 14, 2025
Bacterial laccases exhibit relatively high optimal reaction temperatures and possess a broad substrate spectrum, thereby expanding the range of potential applications for laccase enzymes. This study aims to investigate the molecular evolution of bact...
Copper Amino Acid Sequence Laccase RNA, Ribosomal, 16S Bacterial Proteins Klebsiella Binding Sites Mutagenesis, Site-Directed Cloning, Molecular Enzyme Stability Animals Molecular Docking Simulation
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Prediction of Klebsiella phage-host specificity at the strain level.

Nature communications May 22, 2024
Phages are increasingly considered promising alternatives to target drug-resistant bacterial pathogens. However, their often-narrow host range can make it challenging to find matching phages against bacteria of interest. Current computational tools d...
Computer Simulation Klebsiella Bacteriophages Machine Learning Host Specificity
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Synthesis and in vitro activity of asymmetric indole-based bisamidine compounds against Gram-positive and Gram-negative pathogens.

Bioorganic & medicinal chemistry letters Dec 13, 2019
A series of new asymmetric bisamidine was designed, synthesized, and tested for their in-vitro antibacterial activity using a range of Gram-positive and Gram-negative pathogens. Most compounds demonstrated powerful antibacterial activity, and interes...
Escherichia coli Structure-Activity Relationship Furans Indoles Pseudomonas aeruginosa Molecular Structure Citrobacter freundii Klebsiella Dose-Response Relationship, Drug Anti-Bacterial Agents Microbial Sensitivity Tests
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Rapid identification of pathogenic bacteria using Raman spectroscopy and deep learning.

Nature communications Oct 30, 2019
Raman optical spectroscopy promises label-free bacterial detection, identification, and antibiotic susceptibility testing in a single step. However, achieving clinically relevant speeds and accuracies remains challenging due to weak Raman signal from...
Proteus mirabilis Salmonella enterica Klebsiella Streptococcus Bacterial Typing Techniques Enterococcus Bacterial Infections Principal Component Analysis Pseudomonas aeruginosa Methicillin-Resistant Staphylococcus aureus Candida Humans Neural Networks, Computer Logistic Models Microbial Sensitivity Tests Escherichia coli Anti-Bacterial Agents Single-Cell Analysis Support Vector Machine Staphylococcus aureus Deep Learning Bacteria Spectrum Analysis, Raman
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Monitoring of antimicrobial susceptibility of udder pathogens recovered from cases of clinical mastitis in dairy cows across Europe: VetPath results.

Veterinary microbiology Nov 21, 2017
VetPath is an ongoing pan-European antimicrobial susceptibility monitoring programme collecting pathogens from diseased cattle, pigs and poultry not recently treated with antibiotics. Non-duplicate milk samples were collected from cows with acute cli...
Dairying Mammary Glands, Animal Drug Resistance, Bacterial Streptococcal Infections Streptococcus Europe Anti-Infective Agents Klebsiella Cattle Animals Escherichia coli Infections Mastitis, Bovine Female Klebsiella Infections Microbial Sensitivity Tests Escherichia coli
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Machine learning-assisted substrate binding pocket engineering based on structural information.

Briefings in bioinformatics Jul 25, 2024
Engineering enzyme-substrate binding pockets is the most efficient approach for modifying catalytic activity, but is limited if the substrate binding sites are indistinct. Here, we developed a 3D convolutional neural network for predicting protein-li...
Machine Learning Protein Binding Models, Molecular Neural Networks, Computer Protein Engineering Bacillus anthracis Acid Phosphatase Klebsiella Binding Sites Substrate Specificity Bacterial Proteins Ligands
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