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Cell Nucleolus

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Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli.

Nucleus (Austin, Tex.)
A supervised machine learning algorithm, which is qualified for image classification and analyzing similarities, is based on multiple discriminative morphological features that are automatically assembled during the learning processes. The algorithm ...

Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning.

Nature cell biology
Simultaneous imaging of various facets of intact biological systems across multiple spatiotemporal scales is a long-standing goal in biology and medicine, for which progress is hindered by limits of conventional imaging modalities. Here we propose us...

AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity.

Molecular cancer
BACKGROUND: Immunogenic cell death (ICD) inducers are often identified in phenotypic screening campaigns by the release or surface exposure of various danger-associated molecular patterns (DAMPs) from malignant cells. This study aimed to streamline t...