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Identification of novel markers for neuroblastoma immunoclustering using machine learning.

Frontiers in immunology
BACKGROUND: Due to the unique heterogeneity of neuroblastoma, its treatment and prognosis are closely related to the biological behavior of the tumor. However, the effect of the tumor immune microenvironment on neuroblastoma needs to be investigated,...

Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4.

Computers in biology and medicine
BACKGROUND: Cisplatin-induced ototoxicity remains a significant concern in pediatric cancer treatment due to its permanent impact on quality of life. Previously, genetic association analyses have been performed to detect genetic variants associated w...

Use of Artificial Intelligence in Cobb Angle Measurement for Scoliosis: Retrospective Reliability and Accuracy Study of a Mobile App.

Journal of medical Internet research
BACKGROUND: Scoliosis is a spinal deformity in which one or more spinal segments bend to the side or show vertebral rotation. Some artificial intelligence (AI) apps have already been developed for measuring the Cobb angle in patients with scoliosis. ...

Screening biomarkers for autism spectrum disorder using plasma proteomics combined with machine learning methods.

Clinica chimica acta; international journal of clinical chemistry
BACKGROUND AND AIMS: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder in children. Early intervention is effective. Investigation of novel blood biomarkers of ASD facilitates early detection and intervention.

Clinical and socioeconomic predictors of hospital use and emergency department visits among children with medical complexity: A machine learning approach using administrative data.

PloS one
OBJECTIVES: The primary objective of this study was to identify clinical and socioeconomic predictors of hospital and ED use among children with medical complexity within 1 and 5 years of an initial discharge between 2010 and 2013. A secondary object...

Effects of interval treadmill training on spatiotemporal parameters in children with cerebral palsy: A machine learning approach.

Journal of biomechanics
Quantifying individualized rehabilitation responses and optimizing therapy for each person is challenging. For interventions like treadmill training, there are multiple parameters, such as speed or incline, that can be adjusted throughout sessions. T...

A comprehensive evaluation of an artificial intelligence based digital pathology to monitor large-scale deworming programs against soil-transmitted helminths: A study protocol.

PloS one
BACKGROUND: Manual screening of a Kato-Katz (KK) thick stool smear remains the current standard to monitor the impact of large-scale deworming programs against soil-transmitted helminths (STHs). To improve this diagnostic standard, we recently design...

Charting the growth through intelligence: A SWOC analysis on AI-assisted radiologic bone age estimation.

International journal of legal medicine
Bone age estimation (BAE) is based on skeletal maturity and degenerative process of the skeleton. The clinical importance of BAE is in understanding the pediatric and growth-related disorders; whereas medicolegally it is important in determining crim...

Exploring potential ADHD biomarkers through advanced machine learning: An examination of audiovisual integration networks.

Computers in biology and medicine
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition marked by inattention and impulsivity, linked to disruptions in functional brain connectivity and structural alterations in large-scale brain networks. Although sensory...

A deep-learning-based histopathology classifier for focal cortical dysplasia (FCD) unravels a complex scenario of comorbid FCD subtypes.

Epilepsia
OBJECTIVE: Recently, we developed a first artificial intelligence (AI)-based digital pathology classifier for focal cortical dysplasia (FCD) as defined by the ILAE classification. Herein, we tested the usefulness of the classifier in a retrospective ...