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Chromosome Aberrations

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Ultrasound images-based deep learning radiomics nomogram for preoperative prediction of rearrangement in papillary thyroid carcinoma.

Frontiers in endocrinology
PURPOSE: To create an ultrasound -based deep learning radiomics nomogram (DLRN) for preoperatively predicting the presence of rearrangement among patients with papillary thyroid carcinoma (PTC).

Using deep-learning in fetal ultrasound analysis for diagnosis of cystic hygroma in the first trimester.

PloS one
OBJECTIVE: To develop and internally validate a deep-learning algorithm from fetal ultrasound images for the diagnosis of cystic hygromas in the first trimester.

Dicentric chromosome assay using a deep learning-based automated system.

Scientific reports
The dicentric chromosome assay is the "gold standard" in biodosimetry for estimating radiation exposure. However, its large-scale deployment is limited owing to its time-consuming nature and requirement for expert reviewers. Therefore, a recently dev...

Combined molecular subtyping, grading, and segmentation of glioma using multi-task deep learning.

Neuro-oncology
BACKGROUND: Accurate characterization of glioma is crucial for clinical decision making. A delineation of the tumor is also desirable in the initial decision stages but is time-consuming. Previously, deep learning methods have been developed that can...

Highly Performing Automatic Detection of Structural Chromosomal Abnormalities Using Siamese Architecture.

Journal of molecular biology
The detection of structural chromosomal abnormalities (SCA) is crucial for diagnosis, prognosis and management of many genetic diseases and cancers. This detection, done by highly qualified medical experts, is tedious and time-consuming. We propose a...

Prediction of Bone Marrow Biopsy Results From MRI in Multiple Myeloma Patients Using Deep Learning and Radiomics.

Investigative radiology
OBJECTIVES: In multiple myeloma and its precursor stages, plasma cell infiltration (PCI) and cytogenetic aberrations are important for staging, risk stratification, and response assessment. However, invasive bone marrow (BM) biopsies cannot be perfor...

Cancer cytogenetics in the era of artificial intelligence: shaping the future of chromosome analysis.

Future oncology (London, England)
Artificial intelligence (AI) has rapidly advanced in the past years, particularly in medicine for improved diagnostics. In clinical cytogenetics, AI is becoming crucial for analyzing chromosomal abnormalities and improving precision. However, existin...

Radiation dose estimation with multiple artificial neural networks in dicentric chromosome assay.

International journal of radiation biology
PURPOSE: The dicentric chromosome assay (DCA), often referred to as the 'gold standard' in radiation dose estimation, exhibits significant challenges as a consequence of its labor-intensive nature and dependency on expert knowledge. Existing automate...

Prediction of chromosomal abnormalities in the screening of the first trimester of pregnancy using machine learning methods: a study protocol.

Reproductive health
BACKGROUND: For women in the first trimester, amniocentesis or chorionic villus sampling is recommended for screening. Machine learning has shown increased accuracy over time and finds numerous applications in enhancing decision-making, patient care,...