AIMC Topic: Computational Biology
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Integrating multiple spatial transcriptomics data using community-enhanced graph contrastive learning.
PLoS computational biology
Apr 3, 2025
Due to the rapid development of spatial sequencing technologies, large amounts of spatial transcriptomic datasets have been generated across various technological platforms or different biological conditions (e.g., control vs. treatment). Spatial tra...
Enhancing Enzyme Commission Number Prediction With Contrastive Learning and Agent Attention.
Proteins
Apr 2, 2025
The accurate prediction of enzyme function is crucial for elucidating disease mechanisms and identifying drug targets. Nevertheless, existing enzyme commission (EC) number prediction methods are limited by database coverage and the depth of sequence ...
Identification of novel IL17-related genes as prognostic and therapeutic biomarkers of psoriasis using comprehensive bioinformatics analysis and machine learning.
Scientific reports
Apr 2, 2025
Psoriasis is a common chronic skin disorder with a polygenic background. It is widely acknowledged that Th17/IL-17A axis plays a key role in the pathogenesis of psoriasis. However, numerous regulatory genes upstream of the pathway remain undiscovered...
GONNMDA: A Ordered Message Passing GNN Approach for miRNA-Disease Association Prediction.
Genes
Apr 1, 2025
Small non-coding molecules known as microRNAs (miRNAs) play a critical role in disease diagnosis, treatment, and prognosis evaluation. Traditional wet-lab methods for validating miRNA-disease associations are often time-consuming and inefficient. Wit...
DconnLoop: a deep learning model for predicting chromatin loops based on multi-source data integration.
BMC bioinformatics
Apr 1, 2025
BACKGROUND: Chromatin loops are critical for the three-dimensional organization of the genome and gene regulation. Accurate identification of chromatin loops is essential for understanding the regulatory mechanisms in disease. However, current mainst...
Identification of biomarkers associated with M1 macrophages in the ST-segment elevation myocardial infarction through bioinformatics and machine learning approaches.
Scientific reports
Apr 1, 2025
ST-segment elevation myocardial infarction (STEMI) is considered a critical cardiac condition with a poor prognosis. Shortly after STEMI occurs, the increased number of circulating leukocytes including macrophages can lead to the accumulation of more...
Identification of the potential role of PANoptosis-related genes in burns via bioinformatic analyses and experimental validation.
Burns : journal of the International Society for Burn Injuries
Mar 31, 2025
BACKGROUND: The treatment of burns is highly challenging due to their complex pathophysiological mechanisms. PANoptosis, as an important form of cell death, is suggested to play a crucial role in the inflammatory response and tissue damage following ...
LMFE: A Novel Method for Predicting Plant LncRNA Based on Multi-Feature Fusion and Ensemble Learning.
Genes
Mar 31, 2025
: Long non-coding RNAs (lncRNAs) play a crucial regulatory role in plant trait expression and disease management, making their accurate prediction a key research focus for guiding biological experiments. While extensive studies have been conducted on...
Machine Learning Identification of Neutrophil Extracellular Trap-Related Genes as Potential Biomarkers and Therapeutic Targets for Bronchopulmonary Dysplasia.
International journal of molecular sciences
Mar 31, 2025
Neutrophil extracellular traps (NETs) play a key role in the development of bronchopulmonary dysplasia (BPD), yet their molecular mechanisms in contributing to BPD remain unexplored. Using the GSE32472 dataset, which includes 100 blood samples from p...
optRF: Optimising random forest stability by determining the optimal number of trees.
BMC bioinformatics
Mar 31, 2025
Machine learning is frequently used to make decisions based on big data. Among these techniques, random forest is particularly prominent. Although random forest is known to have many advantages, one aspect that is often overseen is that it is a non-d...
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