Statistical applications in genetics and molecular biology
Jul 1, 2025
The transformer model for sequence mining has brought a paradigmatic shift to many domains, including biological sequence mining. However, transformers suffer from quadratic complexity, i.e., O( ), where is the sequence length, which affects the tra...
Inflammatory bowel disease (IBD) often lacks a definitive diagnostic standard, leading to diagnoses through exclusion. This study aimed to create a predictive model for IBD using bioinformatics and deep learning while identifying potential biomarkers...
Aptamers are oligonucleotide receptors that bind to their targets with high affinity. Here, we consider aptamers comprised of single-stranded DNA that undergo target-binding-induced conformational changes, giving rise to unique secondary and tertiary...
Journal of computational biology : a journal of computational molecular cell biology
Jun 26, 2025
Cancer is a disease that is both complex and diverse, and effective diagnosis and treatment require an accurate depiction of tumor subtypes. Traditional methods of cancer identification, which rely on clinical and histopathological criteria, have lim...
An important issue in biotechnology is predicting whether a piRNA and an mRNA will or will not bind. Research and treatment of diseases, drug discovery, and the silencing and regulation of genes, transposons, and genomic stability may all benefit fro...
Allosteric regulation in proteins is a critical aspect of cellular function, influencing various biological processes through conformational or dynamic changes induced by effector molecules. Allosteric drugs possess significant therapeutic value due ...
Interdisciplinary sciences, computational life sciences
Jun 23, 2025
Emerging evidence highlights long non-coding RNAs (lncRNAs) as pivotal regulators demonstrating significant linkages with diverse human pathologies through expression dynamics and regulatory cascades. This research endeavors to establish an algorithm...
Cell-penetrating peptides (CPPs) have gained significant attention for biomedical applications, including drug delivery and therapeutic development, due to their ability to penetrate cell membranes. The accurate prediction of CPPs is critical for acc...
BACKGROUND: Oxidative stress was one of key factors driving the septic development by the uncontrolled accumulation of free radicals, thus oxidative stress-related biomarkers provide a novel diagnostic option. This study focused on screening oxidativ...
BACKGROUND: Major depressive disorder (MDD) exhibits a multifactorial etiopathogenesis, yet current diagnosis still relies on clinician-rated symptom scales and phenomenological interviews, lacking validated biomarkers.
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.