AIMC Topic: Computer Simulation

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Restricted Boltzmann machines based oversampling and semi-supervised learning for false positive reduction in breast CAD.

Bio-medical materials and engineering Jan 1, 2015
The false-positive reduction (FPR) is a crucial step in the computer aided detection system for the breast. The issues of imbalanced data distribution and the limitation of labeled samples complicate the classification procedure. To overcome these ch...
Breast Neoplasms Stochastic Processes Models, Statistical Radiographic Image Enhancement Sample Size Data Interpretation, Statistical Radiographic Image Interpretation, Computer-Assisted Supervised Machine Learning Pattern Recognition, Automated False Positive Reactions Computer Simulation Female Humans Reproducibility of Results Neural Networks, Computer Sensitivity and Specificity Algorithms
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A novel approach for arrhythmia diagnosis: Self-adaptive and distribution-free mode.

Bio-medical materials and engineering Jan 1, 2015
Arrhythmia diagnosis is very significant to ensure human health. In this paper, a new model is developed for arrhythmia diagnosis. A salient feature of the algorithm is a synergistic combination of statistical and fuzzy set-based techniques. It is di...
Algorithms Computer Simulation Models, Statistical Electrocardiography Arrhythmias, Cardiac Humans Fuzzy Logic
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Why Mathematical Computer Simulations Are the New Laboratory for Scientists.

Substance use & misuse Jan 1, 2015
In this paper, we introduce a new powerful scientific paradigm to understand natural and cultural processes. This new paradigm is based on two fundamental keywords: Data, as representative sample of the process we need to analyze, and Artificial Adap...
Africa, Western Dengue Algorithms Geographic Mapping Mathematical Computing Brazil Research Crime Humans Data Mining Computer Simulation Hemorrhagic Fever, Ebola Epidemics Neural Networks, Computer Reproducibility of Results
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A Multi-Relational Model for Depression Relapse in Patients with Bipolar Disorder.

Studies in health technology and informatics Jan 1, 2015
Bipolar Disorder (BD) is a chronic and disabling disease that usually appears around 20 to 30 years old. Patients who suffer with BD may struggle for years to achieve a correct diagnosis, and only 50% of them generally receive adequate treatment. In ...
Humans Machine Learning Algorithms Computer Simulation Decision Support Systems, Clinical Reproducibility of Results Logistic Models Sensitivity and Specificity Recurrence Diagnosis, Computer-Assisted Depression Bipolar Disorder
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A Baseline Patient Model to Support Testing of Medical Cyber-Physical Systems.

Studies in health technology and informatics Jan 1, 2015
Medical Cyber-Physical Systems (MCPS) are currently a trending topic of research. The main challenges are related to the integration and interoperability of connected medical devices, patient safety, physiologic closed-loop control, and the verificat...
Computer Simulation Data Mining Humans Electronic Health Records Vital Signs Natural Language Processing Patient-Specific Modeling Models, Biological
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Meta-learning framework applied in bioinformatics inference system design.

International journal of data mining and bioinformatics Jan 1, 2015
This paper describes a meta-learner inference system development framework which is applied and tested in the implementation of bioinformatic inference systems. These inference systems are used for the systematic classification of the best candidates...
Models, Biological Pattern Recognition, Automated Sequence Analysis, Protein Signal Transduction Metabolome Meta-Analysis as Topic Bacterial Proteins Algorithms Computer Simulation Bacteria Artificial Intelligence
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Sampling from Determinantal Point Processes for Scalable Manifold Learning.

Information processing in medical imaging : proceedings of the ... conference Jan 1, 2015
High computational costs of manifold learning prohibit its application for large datasets. A common strategy to overcome this problem is to perform dimensionality reduction on selected landmarks and to successively embed the entire dataset with the N...
Head and Neck Neoplasms Models, Statistical Sample Size Data Interpretation, Statistical Reproducibility of Results Sensitivity and Specificity Imaging, Three-Dimensional Signal Processing, Computer-Assisted Radiographic Image Interpretation, Computer-Assisted Pattern Recognition, Automated Radiographic Image Enhancement Humans Artificial Intelligence Algorithms Computer Simulation Tomography, X-Ray Computed
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Computer-Aided Virtual Screening and Designing of Cell-Penetrating Peptides.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2015
Cell-penetrating peptides (CPPs) have proven their potential as versatile drug delivery vehicles. Last decade has witnessed an unprecedented growth in CPP-based research, demonstrating the potential of CPPs as therapeutic candidates. In the past, man...
Humans Machine Learning Computer Simulation Animals Amino Acid Motifs Proteins Amino Acid Sequence Computer-Aided Design Cell-Penetrating Peptides Support Vector Machine Molecular Sequence Data Drug Carriers
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Artificial neural networks for dihedral angles prediction in enzyme loops: a novel approach.

International journal of bioinformatics research and applications Jan 1, 2015
Structure prediction of proteins is considered a limiting step and determining factor in drug development and in the introduction of new therapies. Since the 3D structures of proteins determine their functionalities, prediction of dihedral angles rem...
Molecular Sequence Data Protein Structure, Tertiary Enzymes Sequence Analysis, Protein Neural Networks, Computer Models, Chemical Computer Simulation Amino Acid Sequence Models, Molecular Pattern Recognition, Automated Protein Conformation
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Role of moving average analysis for development of multi-target (Q)SAR models.

Mini reviews in medicinal chemistry Jan 1, 2015
In modern drug discovery era, multi target- quantitative structure activity relationship [mt- (Q)SAR] approaches have emerged as novel and powerful alternatives in the field of in-silico drug design so as to facilitate the discovery of new chemical e...
Humans Artificial Intelligence Computer Simulation Drug Design Quantitative Structure-Activity Relationship Plasmodium falciparum Models, Biological Benzyl Compounds Malaria, Falciparum Trypanosomiasis, African Antiprotozoal Agents Trypanosoma brucei rhodesiense
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