AIMC Topic: Connectome

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Reconfiguration of functional brain hierarchy in schizophrenia.

Translational psychiatry
The multidimensional nature of schizophrenia requires a comprehensive exploration of the functional and structural brain networks. While prior research has provided valuable insights into these aspects, our study goes a step further to investigate th...

Role of the rostral anterior cingulate cortex in emotion processing in Treatment Resistant Depression.

Translational psychiatry
The rostral anterior cingulate cortex (rACC) has been identified as a key region in treatment-resistant depression (TRD), potentially influencing the adaptive interplay between the default mode network and other critical neural networks. This study a...

A deep learning-enriched framework for analyzing brain functional connectivity.

Scientific reports
Cognitive and motor functions require a coordinated communication among brain regions, with the directionality of interactions playing a key role, as the brain relies on functional asymmetries of reciprocal connections. Predictive models based on dee...

Neural oscillation mechanisms of repetitive subconcussive impacts: a network study of microstate-specific cross-frequency coupling.

The journal of headache and pain
BACKGROUND: Repetitive subconcussive impacts are linked to headache pathophysiology, yet the role of electroencephalography (EEG) microstates and cross-frequency coupling in repetitive subconcussive (SC) neural alterations remains unclear. This study...

Linking dynamic connectivity states to cognitive decline and anatomical changes in Alzheimer's disease.

NeuroImage
Alterations in brain connectivity provide early indications of neurodegenerative diseases like Alzheimer's disease (AD). Here, we present a novel framework that integrates a Hidden Markov Model (HMM) within the architecture of a convolutional neural ...

Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease.

Science advances
Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson's disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic stimulation in...

Cognitive prediction using regional connectivities and network biomarkers in Alzheimer's disease.

Neuroscience
Achieving a deep understanding of brain mechanisms requires multi-scale perspectives to capture the architecture of complex networks. In this study, we focused on patients with cognitive impairment and constructed individual brain networks from neuro...

Using deep learning to predict internalizing problems from brain structure in youth.

Translational psychiatry
Internalizing problems (e.g., anxiety and depression) are associated with a wide range of adverse outcomes. While some predictors of internalizing problems are known (e.g., their frequent co-occurrence with neurodevelopmental (ND) conditions), the bi...

High-resolution mapping of alcohol-related brain connectivity in adults using 7T fMRI and multivoxel pattern classification.

Psychiatry research. Neuroimaging
BACKGROUND: Emerging evidence suggests that alcohol use disrupts large-scale brain network interactions, particularly within the triple network model-comprising the Salience Network (SN), Default Mode Network (DMN), and Frontoparietal Network (FPN). ...

Altered effective connectivity in patients with drug-naïve first-episode, recurrent, and medicated major depressive disorder: A multi-site fMRI study.

Behavioural brain research
BACKGROUND: Major depressive disorder (MDD) has been diagnosed through subjective and inconsistent clinical assessments. Resting-state functional magnetic resonance imaging (rs-fMRI) with connectivity analysis has been valuable for identifying neural...