Journal of chemical information and modeling
Jul 22, 2024
Enzyme engineering involves the customization of enzymes by introducing mutations to expand the application scope of natural enzymes. One limitation of that is the complex interaction between two key properties, activity and stability, where the enha...
Journal of chemical information and modeling
Jul 22, 2024
We propose HydraScreen, a deep-learning framework for safe and robust accelerated drug discovery. HydraScreen utilizes a state-of-the-art 3D convolutional neural network designed for the effective representation of molecular structures and interactio...
Deep learning models provide a more powerful method for accurate and stable prediction of water quality in rivers, which is crucial for the intelligent management and control of the water environment. To increase the accuracy of predicting the water ...
Understanding protein function and developing molecular therapies require deciphering the cell types in which proteins act as well as the interactions between proteins. However, modeling protein interactions across biological contexts remains challen...
The journal of physical chemistry letters
Jul 22, 2024
Accurate prediction of Drug-Target Interactions (DTI) is crucial for drug development. Current state-of-the-art deep learning methods have significantly advanced the field; however, these methods exhibit limitations in predictive performance and the ...
BACKGROUND: The diagnosis of solitary pulmonary nodules has always been a difficult and important point in clinical research, especially granulomatous nodules (GNs) with lobulation and spiculation signs, which are easily misdiagnosed as malignant tum...
BMC medical informatics and decision making
Jul 22, 2024
Genes, expressed as sequences of nucleotides, are susceptible to mutations, some of which can lead to cancer. Machine learning and deep learning methods have emerged as vital tools in identifying mutations associated with cancer. Thyroid cancer ranks...
OBJECTIVES: Rheumatoid arthritis (RA) is a severe and common autoimmune disease. Conventional diagnostic methods are often subjective, error-prone, and repetitive works. There is an urgent need for a method to detect RA accurately. Therefore, this st...
Pomegranate is an important fruit crop that is usually managed manually through experience. Intelligent management systems for pomegranate orchards can improve yields and address labor shortages. Fast and accurate detection of pomegranates is one of ...
Frontiers in cellular and infection microbiology
Jul 22, 2024
Human papillomaviruses (HPVs) account for more than 30% of cancer cases, with definite identification of the oncogenic role of viral and genes. However, the identification of high-risk HPV genotypes has largely relied on lagged biological explorati...
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