AIMC Topic: Dopamine Agonists

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Social behavioral profiling by unsupervised deep learning reveals a stimulative effect of dopamine D3 agonists on zebrafish sociality.

Cell reports methods Jan 5, 2023
It has been a major challenge to systematically evaluate and compare how pharmacological perturbations influence social behavioral outcomes. Although some pharmacological agents are known to alter social behavior, precise description and quantificati...
Animals Deep Learning Rats Rats, Sprague-Dawley Zebrafish Dopamine Dopamine Agonists Social Behavior
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Broad clinical spectrum and diverse outcomes of prolactinoma with pediatric onset: medication-resistant and recurrent cases.

Endocrine journal Dec 27, 2017
Prolactinoma is a benign tumor of the pituitary gland that rarely occurs in children and adolescents; thus, the clinical spectrum and long-term prognosis in these patients remain unknown. This study was performed to investigate the long-term outcomes...
Humans Prognosis Retrospective Studies Female Male Adolescent Child Pituitary Neoplasms Prolactinoma Neoplasm Recurrence, Local Sex Factors Age of Onset Prolactin Dopamine Agonists
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Big data-driven target identification by machine learning: DRD2 as a therapeutic target for psoriasis.

Journal of dermatological science Jul 1, 2025
BACKGROUND: The development of medical treatments has traditionally relied on researchers leveraging scientific knowledge to hypothesize disease mechanisms and identify therapeutic agents. However, the depletion of novel therapeutic targets has becom...
Humans Machine Learning Tumor Necrosis Factor-alpha Animals Drug Discovery Big Data Interleukin-17 Mice Disease Models, Animal Psoriasis Skin Imiquimod Molecular Targeted Therapy Dopamine Agonists Receptors, Dopamine D2
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