Understanding how genetic variation impacts transcription factor (TF) binding remains a major challenge, limiting our ability to model disease-associated variants. Here, we used a highly controlled system of F crosses with extensive genetic diversity...
This work presents Neural Optimization for Melting-temperature Enabled by Leveraging Translation (NOMELT), a novel approach for designing and ranking high-temperature stable proteins using neural machine translation. The model, trained on over 4 mill...
Proceedings of the National Academy of Sciences of the United States of America
Apr 8, 2025
Engineering small autonomous agents capable of operating in the microscale environment remains a key challenge, with current systems still evolving. Our study explores the fruit fly, , a classic model system in biology and a species adept at microsca...
There is great interest in using genetically tractable organisms such as to gain insights into the regulation and function of sleep. However, sleep phenotyping in has largely relied on simple measures of locomotor inactivity. Here, we present FlyVI...
Microplastics are widely distributed in the environment and pose potential hazards to organisms. However, our understanding of the transgenerational effects of microplastics on terrestrial organisms remains limited. In this study, we focused on the m...
Accurate prediction of complex traits is an important task in quantitative genetics. Genotypes have been used for trait prediction using a variety of methods such as mixed models, Bayesian methods, penalized regression methods, dimension reduction me...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
DNA N-methyladenine (6mA) is an important epigenetic modification that plays a vital role in various cellular processes. Accurate identification of the 6mA sites is fundamental to elucidate the biological functions and mechanisms of modification. How...
The emergence of microplastics (MPs) has become a significant focus of environmental pollution, prompting widespread concern regarding its potential toxicity and impact on the environment and organisms. Recent research indicates notable alterations i...
One of the key tissue movements driving closure of a wound is re-epithelialisation. Earlier wound healing studies describe the dynamic cell behaviours that contribute to wound re-epithelialisation, including cell division, cell shape changes and cell...
Cell division is fundamental to all healthy tissue growth, as well as being rate-limiting in the tissue repair response to wounding and during cancer progression. However, the role that cell divisions play in tissue growth is a collective one, requir...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.