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Drug Resistance, Microbial

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Molecular mechanisms of antibiotic co-resistance among carbapenem resistant Acinetobacter baumannii.

Journal of infection in developing countries
INTRODUCTION: The spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is difficult to control especially in the hospitals due to the successful mobilization and evolution of the genetic elements harboring the resistant determinants. The stu...

Fate of pirlimycin and antibiotic resistance genes in dairy manure slurries in response to temperature and pH adjustment.

The Science of the total environment
Quantifying the fate of antibiotics and antibiotic resistance genes (ARGs) in response to physicochemical factors during storage of manure slurries will aid in efforts to reduce the spread of resistance when manure is land-applied. The objectives of ...

Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology.

PloS one
Growth in open-source hardware designs combined with the low-cost of high performance optoelectronic and robotics components has supported a resurgence of in-house custom lab equipment development. We describe a low cost (below $700), open-source, fu...

Hierarchical Hidden Markov models enable accurate and diverse detection of antimicrobial resistance sequences.

Communications biology
The characterization of antimicrobial resistance genes from high-throughput sequencing data has become foundational in public health research and regulation. This requires mapping sequence reads to databases of known antimicrobial resistance genes to...

Antibiotic resistance and metabolic profiles as functional biomarkers that accurately predict the geographic origin of city metagenomics samples.

Biology direct
BACKGROUND: The availability of hundreds of city microbiome profiles allows the development of increasingly accurate predictors of the origin of a sample based on its microbiota composition. Typical microbiome studies involve the analysis of bacteria...

VAMPr: VAriant Mapping and Prediction of antibiotic resistance via explainable features and machine learning.

PLoS computational biology
Antimicrobial resistance (AMR) is an increasing threat to public health. Current methods of determining AMR rely on inefficient phenotypic approaches, and there remains incomplete understanding of AMR mechanisms for many pathogen-antimicrobial combin...

Feature selection based multivariate time series forecasting: An application to antibiotic resistance outbreaks prediction.

Artificial intelligence in medicine
Antimicrobial resistance has become one of the most important health problems and global action plans have been proposed globally. Prevention plays a key role in these actions plan and, in this context, we propose the use of Artificial Intelligence, ...

Predicting Antibiotic Resistance in Hospitalized Patients by Applying Machine Learning to Electronic Medical Records.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
BACKGROUND: Computerized decision support systems are becoming increasingly prevalent with advances in data collection and machine learning (ML) algorithms. However, they are scarcely used for empiric antibiotic therapy. Here, we predict the antibiot...