PIWI-interacting RNAs (piRNAs) have been implicated in the biological processes of various cancers. This study aimed to investigate the diagnostic potential of circulating piRNAs in breast cancer (BC) using machine learning (ML) frameworks. A serum t...
BACKGROUND: Breast cancer (BC) remains the second leading cause of cancer-related mortality among women worldwide. Liquid biopsy based on circulating tumor DNA (ctDNA) offers a promising noninvasive approach for early detection; however, differentiat...
Insufficient coverage of cervical cytology screening in resource-limited areas remains a major bottleneck for women's health, as traditional centralized methods require significant investment and many qualified pathologists. Using consumer-grade elec...
European journal of cancer (Oxford, England : 1990)
Aug 10, 2025
IMPORTANCE: Early detection of cutaneous melanoma (CM) is crucial for patient survival, yet avoiding overdiagnosis remains essential. Differentiating CM from benign melanoma simulators (MelSim) is challenging due to overlapping features. Deep learnin...
Cancer of bone marrow is classified as Acute Lymphoblastic Leukemia (ALL), an abnormal growth of lymphoid progenitor cells. It affects both children and adults and is the most predominant form of infantile cancer. Currently, there has been significan...
Pancreatic cancer (PC) is a highly aggressive malignancy in humans, where early diagnosis significantly improves patient outcomes. However, effective methods for accurate and early detection remain limited. In this multiethnic study involving human s...
PURPOSE OF REVIEW: The rising prevalence of obesity, now affecting over 40% of U.S. adults, poses critical implications for colorectal cancer screening, as obesity increases the risk of both colorectal adenomas and cancer. Despite these elevated risk...
Cancer disparities in low- and middle-income countries (LMICs) persist because of socioeconomic inequalities and limited access to screening infrastructure, which requires equitable diagnostic solutions. As researchers, we need to develop interventio...
BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer in the United Kingdom. The five-year survival rate from CRC is only 10% when discovered at a late stage, but can exceed 90% if diagnosed early. Symptoms related to CRC can be non-sp...
BACKGROUND: Deep learning (DL) demonstrates high sensitivity but low specificity in lung cancer (LC) detection during CT screening, and the seven Tumor-associated antigens autoantibodies (7-TAAbs), known for its high specificity in LC, was employed t...
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