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Endpoint Determination

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A prospective, randomized, blinded-endpoint, controlled study - continuous epidural infusion versus programmed intermittent epidural bolus in labor analgesia.

Brazilian journal of anesthesiology (Elsevier)
BACKGROUND: There is evidence that administration of a programmed intermittent epidural bolus (PIEB) compared to continuous epidural infusion (CEI) leads to greater analgesia efficacy and maternal satisfaction with decreased anesthetic interventions.

Recursive Random Forests Enable Better Predictive Performance and Model Interpretation than Variable Selection by LASSO.

Journal of chemical information and modeling
Variable selection is of crucial significance in QSAR modeling since it increases the model predictive ability and reduces noise. The selection of the right variables is far more complicated than the development of predictive models. In this study, e...

Comparative Study of Multitask Toxicity Modeling on a Broad Chemical Space.

Journal of chemical information and modeling
Acute toxicity is one of the most challenging properties to predict purely with computational methods due to its direct relationship to biological interactions. Moreover, toxicity can be represented by different end points: it can be measured for dif...

In-line monitoring and endpoint determination of percolation process of herbal medicine using ultraviolet spectroscopy combined with convolutional neural network.

The Journal of pharmacy and pharmacology
OBJECTIVES: As a common step in the herbal medicine production process, percolation usually lacks effective process monitoring methods and is often conducted with fixed process parameters. In this study, an in-line ultraviolet (UV) spectroscopy was u...

Using deep learning to predict the outcome of live birth from more than 10,000 embryo data.

BMC pregnancy and childbirth
BACKGROUND: Recently, the combination of deep learning and time-lapse imaging provides an objective, standard and scientific solution for embryo selection. However, the reported studies were based on blastocyst formation or clinical pregnancy as the ...

AI-based automation of enrollment criteria and endpoint assessment in clinical trials in liver diseases.

Nature medicine
Clinical trials in metabolic dysfunction-associated steatohepatitis (MASH, formerly known as nonalcoholic steatohepatitis) require histologic scoring for assessment of inclusion criteria and endpoints. However, variability in interpretation has impac...