AIMC Topic: Fluorescent Dyes

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Light-driven microrobots: capture and transport of bacteria and microparticles in a fluid medium.

Journal of materials chemistry. B
The design of simple microrobotic systems with capabilities to address various applications like cargo transportation, as well as biological sample capture and manipulation in an individual unit, provides a novel route for designing advanced multifun...

Similar color analysis based on deep learning (SCAD) for multiplex digital PCR a single fluorescent channel.

Lab on a chip
Digital PCR (dPCR) has recently attracted great interest due to its high sensitivity and accuracy. However, the existing dPCR depends on multicolor fluorescent dyes and multiple fluorescent channels to achieve multiplex detection, resulting in increa...

Preclinical feasibility of robot-assisted sentinel lymph node biopsy using multi-modality magnetic and fluorescence guidance in the head and neck.

Head & neck
BACKGROUND: Sentinel lymph node biopsy (SLNB) is a staging procedure dependent on accurate mapping of draining lymphatics via tracers. Robot-assisted SLNB enables access to multiple neck levels with a single incision and intraoperative fluorescence g...

Microrobotic Swarms for Intracellular Measurement with Enhanced Signal-to-Noise Ratio.

ACS nano
In cell biology, fluorescent dyes are routinely used for biochemical measurements. The traditional global dye treatment method suffers from low signal-to-noise ratios (SNR), especially when used for detecting a low concentration of ions, and increasi...

Fluorescence Analysis of Circulating Exosomes for Breast Cancer Diagnosis Using a Sensor Array and Deep Learning.

ACS sensors
Emerging liquid biopsy methods for investigating biomarkers in bodily fluids such as blood, saliva, or urine can be used to perform noninvasive cancer detection. However, the complexity and heterogeneity of exosomes require improved methods to achiev...

Prediction of Maximum Absorption Wavelength Using Deep Neural Networks.

Journal of chemical information and modeling
Fluorescent molecules are important tools in biological detection, and numerous efforts have been made to develop compounds to meet the desired photophysical properties. For example, tuning the wavelength allows an appropriate penetration depth with ...

Practical Perfusion Quantification in Multispectral Endoscopic Video: Using the Minutes after ICG Administration to Assess Tissue Pathology.

AMIA ... Annual Symposium proceedings. AMIA Symposium
The wide availability of near infrared light sources in interventional medical imaging stacks enables non-invasive quantification of perfusion by using fluorescent dyes, typically Indocyanine Green (ICG). Due to their often leaky and chaotic vasculat...

Deep-learning-assisted Fourier transform imaging spectroscopy for hyperspectral fluorescence imaging.

Scientific reports
Hyperspectral fluorescence imaging is widely used when multiple fluorescent probes with close emission peaks are required. In particular, Fourier transform imaging spectroscopy (FTIS) provides unrivaled spectral resolution; however, the imaging throu...

Intravital deep-tumor single-beam 3-photon, 4-photon, and harmonic microscopy.

eLife
Three-photon excitation has recently been demonstrated as an effective method to perform intravital microscopy in deep, previously inaccessible regions of the mouse brain. The applicability of 3-photon excitation for deep imaging of other, more heter...

Generative adversarial network enables rapid and robust fluorescence lifetime image analysis in live cells.

Communications biology
Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool to quantify molecular compositions and study molecular states in complex cellular environment as the lifetime readings are not biased by fluorophore concentration or excitation power....