OBJECTIVE: IgA nephropathy (IgAN) is the most common form of glomerulonephritis worldwide, characterized by immune complex deposition in the glomerular mesangium, leading to mesangial hypercellularity, persistent microhematuria, proteinuria, and prog...
BACKGROUND: IgA nephropathy (IgAN) is a leading cause of renal failure, characterized by significant clinical and pathological heterogeneity. Accurate subtype classification remains challenging due to overlapping clinical manifestations and the multi...
OBJECTIVES: To develop and validate an ultrasomics-based machine-learning (ML) model for non-invasive assessment of interstitial fibrosis and tubular atrophy (IF/TA) in patients with IgA nephropathy (IgAN).
BACKGROUND: Machine learning (ML) models can help assisting diagnosis by rapidly localising and classifying regions of interest (ROIs) within whole slide images (WSIs). Effective ML models for clinical decision support require a substantial dataset o...
The billing database of the universal healthcare system in Japan potentially includes large-cohort data of patients with immunoglobulin A nephropathy, diagnosis codes aimed at billing should not be directly used for clinical research because of the r...
IgA nephropathy progresses to kidney failure, making early detection important. However, definitive diagnosis depends on invasive kidney biopsy. This study aimed to develop non-invasive prediction models for IgA nephropathy using machine learning. We...
Clinical journal of the American Society of Nephrology : CJASN
May 10, 2024
KEY POINTS: A dynamic model predicts IgA nephropathy prognosis based on deep learning. Longitudinal clinical data and deep learning improve predictive accuracy and interpretability in GN.
This study aimed to develop and validate a combined nomogram model based on superb microvascular imaging (SMI)-based deep learning (DL), radiomics characteristics, and clinical factors for noninvasive differentiation between immunoglobulin A nephropa...
Computer methods and programs in biomedicine
Sep 13, 2023
BACKGROUND AND OBJECTIVE: The Oxford Classification for IgA nephropathy is the most successful example of an evidence-based nephropathology classification system. The aim of our study was to replicate the glomerular components of Oxford scoring with ...
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