BACKGROUND: Severe tubular atrophy/interstitial fibrosis are critical pathological features associated with poor prognosis in IgA nephropathy (IgAN). The early identification of patients at high risk for severe tubular damage could guide clinical man...
Kidney pathology of immunoglobulin A nephropathy (IgAN), which is the key finding of both diagnosis and risk stratification, involves labor-intensive manual interpretation as well as unavoidable interpreter-dependent variabilities. We propose artific...
OBJECTIVE: IgA nephropathy (IgAN) is the most common form of glomerulonephritis worldwide, characterized by immune complex deposition in the glomerular mesangium, leading to mesangial hypercellularity, persistent microhematuria, proteinuria, and prog...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
May 29, 2025
Immunoglobulin A nephropathy (IgAN) and idiopathic membranous nephropathy (IMN) are the most prevalent primary glomerulonephritis (PGN) subtypes and can lead to end-stage renal disease. Conventional diagnostic methods in certain aspects are often lim...
BACKGROUND: IgA nephropathy (IgAN) is a leading cause of renal failure, characterized by significant clinical and pathological heterogeneity. Accurate subtype classification remains challenging due to overlapping clinical manifestations and the multi...
BACKGROUND: Immunoglobulin A nephropathy (IgAN) has a heterogeneous clinical presentation. Comparison of different IgAN subgroups may facilitate the application of more targeted therapies. This study was aimed to distinct disease phenotypes in IgAN a...
OBJECTIVES: To develop and validate an ultrasomics-based machine-learning (ML) model for non-invasive assessment of interstitial fibrosis and tubular atrophy (IF/TA) in patients with IgA nephropathy (IgAN).
BACKGROUND: Machine learning (ML) models can help assisting diagnosis by rapidly localising and classifying regions of interest (ROIs) within whole slide images (WSIs). Effective ML models for clinical decision support require a substantial dataset o...
The billing database of the universal healthcare system in Japan potentially includes large-cohort data of patients with immunoglobulin A nephropathy, diagnosis codes aimed at billing should not be directly used for clinical research because of the r...
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