Journal of chemical information and modeling
Dec 16, 2025
In this study, we pursued a structure-based drug discovery campaign targeting the SARS-CoV-2 helicase through three rounds of virtual screening (VS) enhanced with Artificial Intelligence (AI). The third round incorporated a deep neural network (DNN) ...
Nanomedicine requires smart delivery systems that are precise, robust, and universal. While liposomes are established vehicles in drug delivery, their full potential is challenged by limited stability, leakage, insufficient response, and limited insi...
Endometrial cancer (EC) molecular subtyping is critical for prognosis and treatment but remains hindered by reliance on invasive tissue biopsies and time-consuming genomic sequencing. Here, we present a minimally invasive approach integrating MALDI-T...
Proceedings of the National Academy of Sciences of the United States of America
Dec 16, 2025
Understanding the mortality effects of the most extreme heat events is central to climate change risk analysis and adaptation decision-making. Accurate representation of these impacts requires accounting for the effects of prolonged sequences of hot ...
INTRODUCTION: This study aimed to develop and validate the Artificial Intelligence and Academic Writing Questionnaire (AI-AWQ) to assess participants' perceptions with AI. The primary focus was to explore the factors that influence attitudes toward A...
BACKGROUND: Brain parenchymal tuberculoma (BT) and brain metastases (BM) originating from lung cancer often exhibit overlapping clinical and imaging features, making accurate differentiation challenging. Current diagnostic approaches remain suboptima...
DeepSeek, an AI-driven platform, revolutionizes epidemic management through early warning systems, trend prediction, treatment optimization, and public consultation. By integrating multi-source real-time data (epidemiological, social media, mobility)...
BACKGROUND: The Albumin-Bilirubin (ALBI) grade was initially used to assess liver reserve function in patients with cirrhosis and has since been applied in the prognostic evaluation of various diseases. This study explored the relationship between th...
BACKGROUND: Necrotizing enterocolitis (NEC) is an inflammatory intestinal disease that primarily affects premature infants and is a major cause of death in the neonatal period. Approximately half of the affected infants require surgical intervention,...
Journal of cancer research and clinical oncology
Dec 16, 2025
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a major type of kidney cancer, making up about 80% of cases, with advanced stages showing low survival rates. Current treatments face challenges like toxicity and drug resistance. Studies indicat...
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