AIMC Topic: Insulin

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A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes.

Journal of clinical lipidology
BACKGROUND: Limited data are available that evaluated the effects of combined omega-3 fatty acids and vitamin E supplementation on glucose homeostasis parameters and lipid concentrations in gestational diabetes (GDM).

Long-term clinical and functional impact of biliopancreatic diversion on type 2 diabetes in morbidly and non-morbidly obese patients.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
SETTING: Obesity surgery has been proposed as a treatment option for diabetic patients with body mass index (BMI)<35 kg/m(2), but the efficacy of metabolic surgery has not been conclusively determined.

Cognitively impaired elderly exhibit insulin resistance and no memory improvement with infused insulin.

Neurobiology of aging
Insulin resistance is a risk factor for Alzheimer's disease (AD), although its role in AD etiology is unclear. We assessed insulin resistance using fasting and insulin-stimulated measures in 51 elderly subjects with no dementia (ND; n = 37) and with ...

Insulin improves in vitro survival of equine preantral follicles enclosed in ovarian tissue and reduces reactive oxygen species production after culture.

Theriogenology
This study investigated the effect of insulin concentration on the in vitro culture of equine preantral follicles enclosed in ovarian tissue. Ovarian tissue samples were immediately fixed (noncultured control) or cultured for 1 or 7 days in α-MEM(+) ...

Comparing Deterministic and Stochastic Reinforcement Learning for Glucose Regulation in Type 1 Diabetes.

Studies in health technology and informatics
Type 1 Diabetes (T1D) is a chronic condition affecting millions worldwide, requiring external insulin administration to regulate blood glucose levels and prevent serious complications. Artificial Pancreas Systems (APS) for managing T1D currently rely...

Research Gaps, Challenges, and Opportunities in Automated Insulin Delivery Systems.

Diabetes technology & therapeutics
Since the discovery of the life-saving hormone insulin in 1921 by Dr. Frederick Banting in 1921, there have been many critical discoveries and technical breakthroughs that have enabled people living with type 1 diabetes (T1D) to live longer, healthie...

Neural Networks for On-Chip Model Predictive Control: A Method to Build Optimized Training Datasets and its Application to Type-1 Diabetes.

IEEE transactions on cybernetics
Training neural networks (NNs) to behave as model predictive control (MPC) algorithms is an effective way to implement them in constrained embedded devices. By collecting large amounts of input-output data, where inputs represent system states and ou...

Modulation of insulin aggregation by betaine and proline directly observed via real-time super-resolution microscopy.

Protein science : a publication of the Protein Society
Protein aggregation is associated with a spectrum of neurodegenerative diseases. Although many small ligands have been found to modulate or inhibit protein aggregation, their molecular mechanisms remain unclear. One reason for this is the inherent he...

Machine learning assisted media optimization for enhanced insulin production in Pseudomonas fluorescens cell factory and scale-up studies.

International journal of biological macromolecules
Diabetes mellitus, a chronic metabolic disorder, is characterized by high blood glucose levels. External insulin administration, along with diet and exercise, is recommended to the patients. The increase in the number of diabetics and the adoption of...