AIMC Topic: Intercellular Signaling Peptides and Proteins

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A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway.

Oncogene Aug 1, 2025
Wnt signaling is important in embryonic development and tumorigenesis. These biological effects can be exerted by the activation of the β-catenin-dependent canonical pathway or the β-catenin-independent non-canonical pathway. DKK1 is a potent inhibit...
Cell Line, Tumor Mice Neoplasms Wnt Signaling Pathway Animals Low Density Lipoprotein Receptor-Related Protein-6 Humans Intercellular Signaling Peptides and Proteins Immunotherapy
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CODEX, a neural network approach to explore signaling dynamics landscapes.

Molecular systems biology Apr 1, 2021
Current studies of cell signaling dynamics that use live cell fluorescent biosensors routinely yield thousands of single-cell, heterogeneous, multi-dimensional trajectories. Typically, the extraction of relevant information from time series data reli...
Proto-Oncogene Proteins c-akt Transforming Growth Factor beta Fluorescent Dyes Tumor Suppressor Protein p53 Databases as Topic Intercellular Signaling Peptides and Proteins Light Animals Cell Line Signal Transduction Humans Machine Learning Algorithms Neural Networks, Computer Extracellular Signal-Regulated MAP Kinases Radiation, Ionizing Drosophila Movement Dose-Response Relationship, Radiation
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The association between clinically suspect arthralgia and adipokines in obese patients.

Acta reumatologica portuguesa Jan 1, 2018
OBJECTIVE: Obesity is a moderate low-grade chronic inflammatory condition. The cause of low-grade inflammation in obese patients who have clinically suspect arthralgia (CSA) may be the subject of debate in clinical practice. Our aim is to determine w...
Rheumatic Diseases Arthralgia Chemokines Adipokines Inflammation Female Humans Body Mass Index Male Cytokines Middle Aged Adult Biomarkers Obesity Intercellular Signaling Peptides and Proteins Nicotinamide Phosphoribosyltransferase Leptin
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Chemerin Blood Levels are Associated with MRI Measured Volumes of Abdominal Adipose Tissue Compartments and Lifestyle Choices.

Acta clinica Croatica Dec 1, 2017
Obesity is a low-grade chronic inflammatory state, in which a cytokine chemerin with its immunometabolic modulation has an important role. We aimed to study in a healthy population relationships between serum chemerin levels, lifestyle choices and ma...
Magnetic Resonance Imaging Humans Intra-Abdominal Fat Intercellular Signaling Peptides and Proteins Abdominal Fat Chemokines Life Style Obesity
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