AIMC Topic: Knowledge Bases
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Computational planning of the synthesis of complex natural products.
Nature
Oct 13, 2020
Training algorithms to computationally plan multistep organic syntheses has been a challenge for more than 50 years. However, the field has progressed greatly since the development of early programs such as LHASA, for which reaction choices at each s...
lncRNAKB, a knowledgebase of tissue-specific functional annotation and trait association of long noncoding RNA.
Scientific data
Oct 5, 2020
Long non-coding RNA Knowledgebase (lncRNAKB) is an integrated resource for exploring lncRNA biology in the context of tissue-specificity and disease association. A systematic integration of annotations from six independent databases resulted in 77,19...
Guiding principles for the use of knowledge bases and real-world data in clinical decision support systems: report by an international expert workshop at Karolinska Institutet.
Expert review of clinical pharmacology
Sep 29, 2020
INTRODUCTION: Technical and logical breakthroughs have provided new opportunities in medicine to use knowledge bases and large-scale clinical data (real-world) at point-of-care as part of a learning healthcare system to diminish the knowledge-practic...
Marrying Medical Domain Knowledge With Deep Learning on Electronic Health Records: A Deep Visual Analytics Approach.
Journal of medical Internet research
Sep 28, 2020
BACKGROUND: Deep learning models have attracted significant interest from health care researchers during the last few decades. There have been many studies that apply deep learning to medical applications and achieve promising results. However, there...
MosaicBase: A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Disease-related and Healthy Human Individuals.
Genomics, proteomics & bioinformatics
Sep 8, 2020
Mosaic variants resulting from postzygotic mutations are prevalent in the human genome and play important roles in human diseases. However, except for cancer-related variants, there is no collection of postzygotic mosaic variants in noncancer disease...
Pain-CKB, A Pain-Domain-Specific Chemogenomics Knowledgebase for Target Identification and Systems Pharmacology Research.
Journal of chemical information and modeling
Sep 2, 2020
A traditional single-target analgesic, though it may be highly selective and potent, may not be sufficient to mitigate pain. An alternative strategy for alleviation of pain is to seek simultaneous modulation at multiple nodes in the network of pain-s...
Development of a knowledge translation platform for ataxia: Impact on readers and volunteer contributors.
PloS one
Sep 1, 2020
BACKGROUND: Dissemination of accurate health research information to patients and families has become increasingly important with the rise of the internet as a means of finding health information. However, the public faces several barriers to accessi...
Knowledge-Based Decision Support in Healthcare via Near Field Communication.
Sensors (Basel, Switzerland)
Aug 31, 2020
The benefits of automatic identification technologies in healthcare have been largely recognized. Nevertheless, unlocking their potential to support the most knowledge-intensive medical tasks requires to go beyond mere item identification. This paper...
DZC DIAG: mobile application based on expert system to aid in the diagnosis of dengue, Zika, and chikungunya.
Medical & biological engineering & computing
Aug 26, 2020
Dengue, Zika, and chikungunya are epidemic diseases transmitted by the Aedes mosquito. These virus infections can be so severe to the point of bringing on mobility and neurological problems, or even death. Expert systems (ES) can be used as tools for...
Design and Use of Semantic Resources: Findings from the Section on Knowledge Representation and Management of the 2020 International Medical Informatics Association Yearbook.
Yearbook of medical informatics
Aug 21, 2020
OBJECTIVE: To select, present, and summarize the best papers in the field of Knowledge Representation and Management (KRM) published in 2019.
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