AIMC Topic: Knowledge Bases

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ViralZone 2024 provides higher-resolution images and advanced virus-specific resources.

Nucleic acids research Jan 5, 2024
ViralZone (http://viralzone.expasy.org) is a knowledge repository for viruses that links biological knowledge and databases. It contains data on virion structure, genome, proteome, replication cycle and host-virus interactions. The new update provide...
Virion Knowledge Bases Viruses Humans
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SLKB: synthetic lethality knowledge base.

Nucleic acids research Jan 5, 2024
Emerging CRISPR-Cas9 technology permits synthetic lethality (SL) screening of large number of gene pairs from gene combination double knockout (CDKO) experiments. However, the poor integration and annotation of CDKO SL data in current SL databases li...
Humans Synthetic Lethal Mutations Knowledge Bases Internet Use RNA, Guide, CRISPR-Cas Systems
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HervD Atlas: a curated knowledgebase of associations between human endogenous retroviruses and diseases.

Nucleic acids research Jan 5, 2024
Human endogenous retroviruses (HERVs), as remnants of ancient exogenous retrovirus infected and integrated into germ cells, comprise ∼8% of the human genome. These HERVs have been implicated in numerous diseases, and extensive research has been condu...
Humans Knowledge Bases Internet Use Endogenous Retroviruses Virus Diseases Atlases as Topic
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ASD2023: towards the integrating landscapes of allosteric knowledgebase.

Nucleic acids research Jan 5, 2024
Allosteric regulation, induced by perturbations at an allosteric site topographically distinct from the orthosteric site, is one of the most direct and efficient ways to fine-tune macromolecular function. The Allosteric Database (ASD; accessible onli...
Knowledge Bases Ligands Allosteric Site Allosteric Regulation Protein Interaction Maps Proteome Humans Drug Discovery
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AgeAnnoMO: a knowledgebase of multi-omics annotation for animal aging.

Nucleic acids research Jan 5, 2024
Aging entails gradual functional decline influenced by interconnected factors. Multiple hallmarks proposed as common and conserved underlying denominators of aging on the molecular, cellular and systemic levels across multiple species. Thus, understa...
Multiomics Knowledge Bases Longevity Animals Humans Aging Biomarkers
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BioKA: a curated and integrated biomarker knowledgebase for animals.

Nucleic acids research Jan 5, 2024
Biomarkers play an important role in various area such as personalized medicine, drug development, clinical care, and molecule breeding. However, existing animals' biomarker resources predominantly focus on human diseases, leaving a significant gap i...
Proteins Knowledge Bases RNA, Circular MicroRNAs Biomarkers Animals RNA, Long Noncoding
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Modeling Precision Feedback Knowledge for Healthcare Professional Learning and Quality Improvement.

AMIA ... Annual Symposium proceedings. AMIA Symposium Jan 1, 2024
Healthcare providers learn continuously, but better support for provider learning is needed as new biomedical knowledge is produced at an increasing rate alongside widespread use of EHR data for clinical performance measurement. Precision feedback is...
Feedback Learning Health System Health Personnel Learning Formative Feedback Knowledge Bases Quality Improvement Humans
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Structured Knowledge Base Enhances Effective Use of Large Language Models for Metadata Curation.

AMIA ... Annual Symposium proceedings. AMIA Symposium Jan 1, 2024
field name-field value
Humans Data Curation Large Language Models Knowledge Bases Lung Neoplasms Metadata Natural Language Processing
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MKRAG: Medical Knowledge Retrieval Augmented Generation for Medical Question Answering.

AMIA ... Annual Symposium proceedings. AMIA Symposium Jan 1, 2024
Large Language Models (LLMs), although powerful in general domains, often perform poorly on domain-specific tasks such as medical question answering (QA). In addition, LLMs tend to function as "black-boxes", making it challenging to modify their beha...
Knowledge Bases Information Storage and Retrieval Humans Natural Language Processing
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A Comprehensive System for Searching and Evaluating Genomic Variant Evidence Using AI and Knowledge Bases to Support Personalized Medicine.

AMIA ... Annual Symposium proceedings. AMIA Symposium Jan 1, 2024
We introduce an innovative automated system for the search and assessment of genetic variant evidence, meticulously aligned with ACMG guidelines. Leveraging the synergistic power of artificial intelligence (AI), elastic search, and an extensive knowl...
Knowledge Bases Humans Genetic Variation Artificial Intelligence Precision Medicine Genomics
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