AIMC Topic: Liquid Chromatography-Mass Spectrometry

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Discovery of urinary biosignatures for tuberculosis and nontuberculous mycobacteria classification using metabolomics and machine learning.

Scientific reports Jul 3, 2024
Nontuberculous mycobacteria (NTM) infection diagnosis remains a challenge due to its overlapping clinical symptoms with tuberculosis (TB), leading to inappropriate treatment. Herein, we employed noninvasive metabolic phenotyping coupled with comprehe...
Amino Acids Random Forest Diagnosis, Differential Area Under Curve Down-Regulation Up-Regulation Tuberculosis Mycobacterium Infections, Nontuberculous ROC Curve Metabolomics Liquid Chromatography-Mass Spectrometry Metabolome Models, Statistical Male Middle Aged Biomarkers Aged Machine Learning Phenotype Humans
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BERNN: Enhancing classification of Liquid Chromatography Mass Spectrometry data with batch effect removal neural networks.

Nature communications May 6, 2024
Liquid Chromatography Mass Spectrometry (LC-MS) is a powerful method for profiling complex biological samples. However, batch effects typically arise from differences in sample processing protocols, experimental conditions, and data acquisition techn...
Reproducibility of Results Neural Networks, Computer Liquid Chromatography-Mass Spectrometry
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Enhancing pyrrolizidine alkaloid separation and detection: LC-MS/MS method development and integration of ion mobility spectrometry into the LC-HRMS workflow.

Journal of chromatography. A May 10, 2025
Pyrrolizidine alkaloids (PAs) are plant toxins occurring in different foodstuffs, including teas, herbal infusions and species. Additionally, PAs may be transferred to honey and pollen when honeybees come into contact with contaminated plants. Due to...
Liquid Chromatography-Mass Spectrometry Limit of Detection Food Analysis Chromatography, Liquid Linear Models Ion Mobility Spectrometry Reproducibility of Results Pyrrolizidine Alkaloids Food Contamination Tandem Mass Spectrometry Honey
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Benzoyl Chloride Derivatization Coupled With Liquid Chromatography-Mass Spectrometry for the Simultaneous Quantification of Molnupiravir and Its Metabolite β-d-N-hydroxycytidine in Human Plasma.

Journal of separation science May 1, 2025
A sensitive and efficient method for simultaneous quantifying molnupiravir and its active metabolite β-d-N-hydroxycytidine in human plasma was developed by combining chemical derivatization with liquid chromatography-tandem mass spectrometry. Through...
Tandem Mass Spectrometry Cytidine Molecular Structure Chromatography, High Pressure Liquid Hydroxylamines Chromatography, Liquid Humans Liquid Chromatography-Mass Spectrometry
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LC-MS/MS-Based Assay for Steroid Profiling in Peripheral and Adrenal Venous Samples for the Subtyping of Primary Aldosteronism.

Journal of clinical hypertension (Greenwich, Conn.) May 1, 2025
Given the largely unexplored application of liquid chromatography-tandem mass spectrometry (LC-MS/MS) steroid analysis in primary aldosteronism (PA), we aimed to investigate its diagnostic utility in PA classification and to characterize steroid secr...
Chromatography, Liquid Liquid Chromatography-Mass Spectrometry Hydrocortisone Aldosterone Hyperaldosteronism Retrospective Studies Veins Female Tandem Mass Spectrometry Adult Aged Adrenal Glands Male Middle Aged Humans Steroids
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Prediction of Anti-rheumatoid Arthritis Natural Products of Xanthocerais Lignum Based on LC-MS and Artificial Intelligence.

Combinatorial chemistry & high throughput screening Jan 1, 2025
AIMS: Employing the technique of liquid chromatography-mass spectrometry (LCMS) in conjunction with artificial intelligence (AI) technology to predict and screen for antirheumatoid arthritis (RA) active compounds in Xanthocerais lignum.
Humans Chromatography, Liquid Liquid Chromatography-Mass Spectrometry Antirheumatic Agents Mass Spectrometry Biological Products Artificial Intelligence Arthritis, Rheumatoid
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UPLC-MS/MS Method for Detection of Etomidate and Its Metabolite Etomidate Acid Quantity in Blood.

Fa yi xue za zhi Dec 25, 2023
OBJECTIVES: To establish a method for the simultaneous quantitative analysis of etomidate and its metabolite etomidate acid in blood, and to discuss its application value in actual cases.
Tandem Mass Spectrometry Acetonitriles Chromatography, High Pressure Liquid Chromatography, Liquid Etomidate Liquid Chromatography-Mass Spectrometry
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