AIMC Topic: Liver Cirrhosis

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Identifying liver cirrhosis in patients with chronic hepatitis B: an interpretable machine learning algorithm based on LSM.

Annals of medicine Dec 1, 2025
BACKGROUND: Chronic hepatitis B (CHB) is a common cause of liver cirrhosis (LC), a condition associated with an unfavourable prognosis. Therefore, timely diagnosis of LC in CHB patients is crucial.
Hepatitis B, Chronic Elasticity Imaging Techniques Neural Networks, Computer ROC Curve Machine Learning Logistic Models Algorithms Liver Cirrhosis Retrospective Studies Liver Female Adult Male Middle Aged Humans
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Machine Learning-Based Biomarker Identification for Early Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease.

The Journal of clinical endocrinology and metabolism Oct 16, 2025
CONTEXT: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an umbrella term for simple hepatic steatosis and the more severe metabolic dysfunction-associated steatohepatitis. The current reliance on liver biopsy for diagnosis and a ...
Biomarkers Female Humans Liver Cirrhosis Early Diagnosis Aged Male Nutrition Surveys Machine Learning Metabolic Diseases Middle Aged Adult Elasticity Imaging Techniques Case-Control Studies Fatty Liver
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Deep Learning-Enhanced CTA for Noninvasive Prediction of First Variceal Haemorrhage in Cirrhosis: A Multi-Centre Study.

Liver international : official journal of the International Association for the Study of the Liver Sep 1, 2025
BACKGROUND AND AIMS: The first variceal haemorrhage (FVH) is a life-threatening complication of liver cirrhosis that requires timely intervention; however, noninvasive tools for accurately predicting FVH remain limited. This study aimed to develop no...
Adult Male Middle Aged Deep Learning Humans Retrospective Studies Female Aged Gastrointestinal Hemorrhage Computed Tomography Angiography ROC Curve Liver Cirrhosis Predictive Value of Tests Esophageal and Gastric Varices
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Development of AI Based Fibrosis Detection Algorithm by SHG/TPEF Microscopy for Fully Quantified Liver Fibrosis Assessment in MASH.

Liver international : official journal of the International Association for the Study of the Liver Sep 1, 2025
BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major global cause of chronic liver disease, with the potential to progress from steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and cirrh...
Second Harmonic Generation Microscopy Machine Learning Liver Detection Algorithms Algorithms Humans Biopsy Fatty Liver Artificial Intelligence Collagen Liver Cirrhosis Microscopy, Fluorescence, Multiphoton
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Enhancing HF-DL Model Validation for Liver Fibrosis Staging Through Sample Optimisation and Technical Integration.

Liver international : official journal of the International Association for the Study of the Liver Aug 1, 2025
We read with great interest the article by Zhang et al. The study demonstrates that the deep learning model based on high-frequency ultrasound images significantly outperforms the low-frequency ultrasound model, FIB-4, APRI, and shear wave elastograp...
Liver Cirrhosis Liver Hepatitis B, Chronic Elasticity Imaging Techniques Humans Severity of Illness Index Deep Learning Ultrasonography
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Digital Pathology Quantification of the Continuum of Cirrhosis Severity in Human Liver Biopsies.

Liver international : official journal of the International Association for the Study of the Liver Jul 1, 2025
BACKGROUND AND AIMS: Liver biopsy is the gold standard for assessing fibrosis in cirrhotic livers, yet cirrhosis is spatially heterogeneous and continuously remodels. This study evaluates a novel phenotypic digital pathology platform for continuous f...
Humans Female Aged Adult Male Middle Aged Liver Transplantation Severity of Illness Index Biopsy, Needle Liver Cirrhosis Liver Biopsy
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A Deep Learning Model Based on High-Frequency Ultrasound Images for Classification of Different Stages of Liver Fibrosis.

Liver international : official journal of the International Association for the Study of the Liver Jul 1, 2025
BACKGROUND AND AIMS: To develop a deep learning model based on high-frequency ultrasound images to classify different stages of liver fibrosis in chronic hepatitis B patients.
Liver Hepatitis B, Chronic Retrospective Studies Female Adult Deep Learning Male Humans Middle Aged Ultrasonography Algorithms Liver Cirrhosis Severity of Illness Index
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Differentiating benign and hepatocellular carcinoma cirrhotic nodules: radiomics analysis of water restriction patterns with diffusion MRI.

The British journal of radiology Jul 1, 2025
OBJECTIVES: Current study aimed to investigate radiomics features derived from 2-centre diffusion-MRI to differentiate benign and hepatocellular carcinoma (HCC) liver nodules.
Male Middle Aged Liver Neoplasms Carcinoma, Hepatocellular Female Liver Cirrhosis Humans Aged Support Vector Machine Retrospective Studies Adult Diagnosis, Differential Radiomics Diffusion Magnetic Resonance Imaging
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Multiple machine learning algorithms identify 13 types of cell death-critical genes in large and multiple non-alcoholic steatohepatitis cohorts.

Lipids in health and disease May 8, 2025
BACKGROUND: Dysregulated programmed cell death pathways mechanistically contribute to hepatic inflammation and fibrogenesis in non-alcoholic steatohepatitis (NASH). Identification of cell death genes may offer insights into diagnostic and therapeutic...
Cohort Studies Inflammation Liver Cirrhosis Liver Lipid Metabolism Algorithms Humans Non-alcoholic Fatty Liver Disease Female Machine Learning Male Cell Death Gene Expression Profiling
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The Association Between Hepatocellular Carcinoma and Gastrointestinal Adenocarcinoma: Is This a New Syndrome in Patients With Cirrhosis? A Case Series.

Cancer reports (Hoboken, N.J.) May 1, 2025
AIM: This case series aimed to explore the occurrence of synchronous hepatocellular carcinoma (HCC) and gastrointestinal adenocarcinoma in cirrhotic patients and to propose a potential common pathogenic mechanism.
Liver Cirrhosis Aged, 80 and over Humans Wnt Signaling Pathway Adenocarcinoma Male Retrospective Studies Neoplasms, Multiple Primary Liver Neoplasms Microsatellite Instability Female Carcinoma, Hepatocellular Gastrointestinal Neoplasms Aged
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