Deciphering the pre-malignant cell of origin (COO) of different cancers is critical for understanding tumor development and improving diagnostic and therapeutic strategies in oncology. Prior work demonstrates that somatic mutations preferentially acc...
BACKGROUND: Emergency department (ED) overcrowding remains a critical challenge, leading to delays in patient care and increased operational strain. Current hospital management strategies often rely on reactive decision-making, addressing congestion ...
BACKGROUND: Cervical cancer has been ranked as the fourth most common cancer affecting women, contributing to approximately 660,000 new diagnoses and 350,000 fatalities worldwide. Effective early screening has been shown to reduce cervical cancer inc...
OBJECTIVE: The aim of this study was to assess measurements of the maxillary canines using Cone Beam Computed Tomography (CBCT) and develop a machine learning model for sex estimation.
BACKGROUND: Mental health challenges are prevalent among Canadian higher education students, with significant rates of depression and anxiety often going untreated due to reduced early detection, stigmatizing beliefs, and practical barriers. The U-Fl...
In the context of global economic austerity in the post epidemic era, housing, as one of the basic human needs, has become particularly important for accurate prediction of house prices. BP neural network is widely used in prediction tasks, but their...
BACKGROUND: Renal dysfunction is a frequent and clinically relevant complication of cirrhosis, yet chronic kidney disease (CKD) often remains underrecognized, particularly in non-acute settings. Early identification of at-risk patients is essential t...
The quality of strong-flavor Baijiu (SFB) is directly determined by key flavor compounds, which are influenced by microorganisms during fermentation. This study employed flavoromics and machine learning technologies to explore the relationship betwee...
Journal of chemical theory and computation
Sep 16, 2025
Biased allosteric modulators (BAMs) offer a promising avenue for developing safer and more selective therapeutics for G protein-coupled receptors (GPCRs). However, their molecular mechanisms remain unclear due to the complex combination of biased and...
Journal of chemical information and modeling
Sep 16, 2025
RNA molecules play diverse and critical roles in various biological processes, including gene expression, post-transcriptional regulation, and disease pathogenesis. Understanding the interaction between proteins and RNA necessitates the precise ident...
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