Enzymes are important and effective biological catalyst proteins participating in almost all active cell processes. Identification of multi-functional enzymes is essential in understanding the function of enzymes. Machine learning methods perform bet...
IEEE transactions on bio-medical engineering
Apr 13, 2016
Sparse learning has been widely investigated for analysis of brain images to assist the diagnosis of Alzheimer's disease and its prodromal stage, i.e., mild cognitive impairment. However, most existing sparse learning-based studies only adopt cross-s...
Probabilities can be consistently estimated using random forests. It is, however, unclear how random forests should be updated to make predictions for other centers or at different time points. In this work, we present two approaches for updating ran...
Neural networks : the official journal of the International Neural Network Society
Apr 12, 2016
The restricted Boltzmann machine (RBM) is an essential constituent of deep learning, but it is hard to train by using maximum likelihood (ML) learning, which minimizes the Kullback-Leibler (KL) divergence. Instead, contrastive divergence (CD) learnin...
The identification of individual-cancer-related genes typically is an imbalanced classification issue. The number of known cancer-related genes is far less than the number of all unknown genes, which makes it very hard to detect novel predictions fro...
BACKGROUND: In the context of drug discovery, drug target interactions (DTIs) can be predicted based on observed topological features of a semantic network across the chemical and biological space. In a semantic network, the types of the nodes and li...
International journal of neural systems
Apr 11, 2016
Effective common spatial pattern (CSP) feature extraction for motor imagery (MI) electroencephalogram (EEG) recordings usually depends on the filter band selection to a large extent. Subband optimization has been suggested to enhance classification a...
Neural networks : the official journal of the International Neural Network Society
Apr 8, 2016
This paper presents the first hardware implementation of neuro-fuzzy system (NFS) with its metaheuristic learning ability on field programmable gate array (FPGA). Metaheuristic learning of NFS for all of its parameters is accomplished by using the im...
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Apr 8, 2016
Automatic vertebra recognition, including the identification of vertebra locations and naming in multiple image modalities, are highly demanded in spinal clinical diagnoses where large amount of imaging data from various of modalities are frequently ...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 7, 2016
Glioblastoma multiforme (GBM) is a highly aggressive type of brain cancer with very low median survival. In order to predict the patient's prognosis, researchers have proposed rules to classify different glioma cancer cell subtypes. However, survival...
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