AIMC Topic: Marfan Syndrome

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Perivascular inflammation in the progression of aortic aneurysms in Marfan syndrome.

JCI insight Aug 28, 2025
Inflammation plays important roles in the pathogenesis of vascular diseases. We here show the involvement of perivascular inflammation in aortic dilatation of Marfan syndrome (MFS). In the aorta of patients with MFS and Fbn1C1041G/+ mice, macrophages...
Humans Macrophages Female Adult Animals Male Middle Aged Disease Progression Mice Inflammation Disease Models, Animal Mice, Inbred C57BL Diet, High-Fat Adipose Tissue Transforming Growth Factor beta Quinolines Aorta Aortic Aneurysm Marfan Syndrome Fibrillin-1
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Systematical analysis of underlying markers associated with Marfan syndrome via integrated bioinformatics and machine learning strategies.

Journal of biomolecular structure & dynamics Jul 14, 2023
Marfan syndrome (MFS) is a hereditary disease with high mortality. This study aimed to explore peripheral blood potential markers and underlying mechanisms in MFS via a series bioinformatics and machine learning analysis. First, we downloaded two MFS...
Humans Machine Learning Algorithms Biomarkers Gene Expression Profiling ROC Curve Protein Interaction Maps Gene Regulatory Networks Computational Biology Databases, Genetic MicroRNAs Gene Expression Regulation Marfan Syndrome
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