The Journal of clinical investigation
Jun 16, 2025
As antimicrobial resistance rises, new antibacterial candidates are urgently needed. Using sequence space information from over 14,743 functional antimicrobial peptides (AMPs), we improved the antimicrobial properties of citropin 1.1, an AMP with wea...
Clinica chimica acta; international journal of clinical chemistry
Jun 15, 2025
OBJECTIVES: The World Health Organization has identified Klebsiella pneumoniae (KP) and Pseudomonas aeruginosa (PA) as significant public health threats owing to high antibiotic resistance. Traditional antibiotic susceptibility testing (AST) methods,...
Non-ribosomal peptides (NRPs) are promising lead compounds for novel antibiotics. Bioinformatic mining of silent microbial NRPS gene clusters provide crucial insights for the discovery and de novo design of bioactive peptides. Here, we describe the e...
The journal of physical chemistry letters
Jun 12, 2025
The growing prevalence of infectious diseases and the increasing threat of bacterial resistance have drawn widespread attention to antimicrobial inorganic nanomaterials. However, the diversity, abundance, and complex mechanisms of these materials pre...
Journal of infection in developing countries
May 31, 2025
INTRODUCTION: Antimicrobial resistance (AMR) is a global health challenge, and antimicrobial susceptibility testing (AST) is vital for guiding treatment. Although widely used, the Kirby-Bauer method depends on skilled interpretation, which can be tim...
Carbapenem resistance and hypervirulence represent two distinct evolutionary pathways in , posing significant challenges in clinical settings. Of particular concern are convergent strains that combine both traits, complicating timely diagnosis and tr...
Identifying host defense peptides (HDPs) that are effective against drug-resistant infections is challenging due to their vast sequence space. Artificial intelligence (AI)-guided design can accelerate HDP discovery, but it traditionally requires larg...
The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis. Therefore, it is an important target f...
Antimicrobial peptides (AMPs) face stability and toxicity challenges in clinical use. Stapled modification enhances their stability and effectiveness, but its application in peptide design is rarely reported. This study built ten prediction models fo...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Although MALDI-TOF mass spectrometry (MS) is considered as the gold standard for rapid and cost-effective identification of microorganisms in routine laboratory practices, its capability for antimicrobial resistance (AMR) detection has received limit...
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