AI Medical Compendium Topic

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Microscopy, Interference

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Unsupervised delineation of stratum corneum using reflectance confocal microscopy and spectral clustering.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
BACKGROUND: Measuring the thickness of the stratum corneum (SC) in vivo is often required in pharmacological, dermatological, and cosmetological studies. Reflectance confocal microscopy (RCM) offers a non-invasive imaging-based approach. However, RCM...

Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning.

Scientific reports
In the last decade, high-content screening based on multivariate single-cell imaging has been proven effective in drug discovery to evaluate drug-induced phenotypic variations. Unfortunately, this method inherently requires fluorescent labeling which...

Low coherence quantitative phase microscopy with machine learning model and Raman spectroscopy for the study of breast cancer cells and their classification.

Applied optics
Early-stage detection of breast cancer is the primary requirement in modern healthcare as it is the most common cancer among women worldwide. Histopathology is the most widely preferred method for the diagnosis of breast cancer, but it requires long ...

Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments.

Nature communications
Due to its specificity, fluorescence microscopy has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit fluorescence microscopy's utility. Recently, it has been shown t...

High-resolution single-shot phase-shifting interference microscopy using deep neural network for quantitative phase imaging of biological samples.

Journal of biophotonics
White light phase-shifting interference microscopy (WL-PSIM) is a prominent technique for high-resolution quantitative phase imaging (QPI) of industrial and biological specimens. However, multiple interferograms with accurate phase-shifts are essenti...

Automatic Colorectal Cancer Screening Using Deep Learning in Spatial Light Interference Microscopy Data.

Cells
The surgical pathology workflow currently adopted by clinics uses staining to reveal tissue architecture within thin sections. A trained pathologist then conducts a visual examination of these slices and, since the investigation is based on an empiri...