AI Medical Compendium Topic

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Models, Biological

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Forecasting and Predicting Stochastic Agent-Based Model Data with Biologically-Informed Neural Networks.

Bulletin of mathematical biology
Collective migration is an important component of many biological processes, including wound healing, tumorigenesis, and embryo development. Spatial agent-based models (ABMs) are often used to model collective migration, but it is challenging to thor...

Modelling human postural stability and muscle activation augmented by a supernumerary robotic tail.

Bioinspiration & biomimetics
Wearable robots have promising characteristics for human augmentation; however, the the design and specification stage needs to consider biomechanical impact. In this work, musculoskeletal software is used to assess the biomechanical implications of ...

Optimization of fungal secondary metabolites production via response surface methodology coupled with multi-parameter optimized artificial neural network model.

Bioresource technology
Filamentous fungi's secondary metabolites (SMs) possess significant application owing to their distinct structure and diverse bioactivities, yet their restricted yield levels often hinder further research and application. The study developed a respon...

Real-Time Calibration-Free Musculotendon Kinematics for Neuromusculoskeletal Models.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Neuromusculoskeletal (NMS) models enable non-invasive estimation of clinically important internal biomechanics. A critical part of NMS modelling is the estimation of musculotendon kinematics, which comprise musculotendon unit lengths, moment arms, an...

Physics-informed neural networks for biopharmaceutical cultivation processes: Consideration of varying process parameter settings.

Biotechnology and bioengineering
We present a new modeling approach for the study and prediction of important process outcomes of biotechnological cultivation processes under the influence of process parameter variations. Our model is based on physics-informed neural networks (PINNs...

A Multi-Omics, Machine Learning-Aware, Genome-Wide Metabolic Model of Bacillus Subtilis Refines the Gene Expression and Cell Growth Prediction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Given the extensive heterogeneity and variability, understanding cellular functions and regulatory mechanisms through the analysis of multi-omics datasets becomes extremely challenging. Here, a comprehensive modeling framework of multi-omics machine ...

Comparison of feed-forward control strategies for simplified vertical hopping model with intrinsic muscle properties.

Bioinspiration & biomimetics
To analyse walking, running or hopping motions, models with high degrees of freedom are usually used. However simple reductionist models are advantageous within certain limits. In a simple manner, the hopping motion is generally modelled by a spring-...

Dose Individualisation of Antimicrobials from a Pharmacometric Standpoint: The Current Landscape.

Drugs
Successful antimicrobial therapy depends on achieving optimal drug concentrations within individual patients. Inter-patient variability in pharmacokinetics (PK) and differences in pathogen susceptibility (reflected in the minimum inhibitory concentra...

Bioinspired deformation computational design method for muscle-driven soft robots using MPM.

Bioinspiration & biomimetics
In order to adapt to complex and changing environments, animals have a wide variety of locomotor forms, which has inspired the investigation of their deformation and driving mechanisms. In this paper, we propose a computational design method for musc...

Towards higher load capacity: innovative design of a robotic hand with soft jointed structure.

Bioinspiration & biomimetics
In this paper, the innovative design of a robotic hand with soft jointed structure is carried out and a tendon-driven mechanism, a master-slave motor coordinated drive mechanism, a thumb coupling transmission mechanism and a thumb steering mechanism ...