Animals have evolved highly effective locomotion capabilities in terrestrial, aerial, and aquatic environments. Over life's history, mass extinctions have wiped out unique animal species with specialized adaptations, leaving paleontologists to recons...
The human toe, characterized by its rigid-flexible structure comprising hard bones and flexible joints, facilitates adaptive and stable movement across varied terrains. In this paper, we utilized a motion capture system to study the adaptive adjustme...
The genome-scale metabolic model (GEM) has emerged as one of the leading modeling approaches for systems-level metabolic studies and has been widely explored for a broad range of organisms and applications. Owing to the development of genome sequenci...
Models of physical phenomena can be developed using two distinct approaches: using expert knowledge of the underlying physical principles or using experimental data to train a neural network. Here, our aim was to better understand the advantages and ...
Clinical pharmacology and therapeutics
May 6, 2024
Levothyroxine is one of the most prescribed drugs in the western world. Dosing is challenging due to high-interindividual differences in effective dosage and the narrow therapeutic window. Model-informed precision dosing (MIPD) using machine learning...
CONTEXT: Computational modeling involves the use of computer simulations and models to study and understand real-world phenomena. Its application is particularly relevant in the study of potential interactions between biological elements. It is a pro...
Clinical trials involving systemic neoadjuvant treatments in breast cancer aim to shrink tumors before surgery while simultaneously allowing for controlled evaluation of biomarkers, toxicity, and suppression of distant (occult) metastatic disease. Ye...
Medical & biological engineering & computing
May 2, 2024
Accurate determination of body segment parameters is crucial for studying human movement and joint forces using musculoskeletal (MSK) models. However, existing methods for predicting segment mass have limited generalizability and sensitivity to body ...
This paper is concerned with a kind of Bobwhite quail population model where the parameters and initial values are positive parabolic fuzzy numbers. According to g-division of fuzzy sets and based on the symmetrical parabolic fuzzy numbers, the cond...
BACKGROUND: Pathogenic parasites are responsible for multiple diseases, such as malaria and Chagas disease, in humans and livestock. Traditionally, pathogenic parasites have been largely an evasive topic for vaccine design, with most successful vacci...