OBJECTIVE: Quantitative systems pharmacology (QSP) is widely used to assess drug effects and toxicity before the drug goes to clinical trial. However, significant manual distillation of the literature is needed in order to construct a QSP model. Para...
For flying insects, the transition from flight to surface locomotion requires effective touchdown maneuvers that allow stable landings on a variety of surfaces. Landing behaviors of insects are diverse, with some using more controlled flight approach...
Artificial neural networks (ANNs) are becoming a regular tool to support biomechanical methods, while physics-based models are widespread to understand the mechanics of body in motion. Thus, this study aimed to demonstrate the accuracy of recurrent A...
Biomechanics and modeling in mechanobiology
Apr 8, 2025
This paper presents a mathematical and numerical framework for modelling and parametrising tumour evolution dynamics to enhance computer-aided diagnosis and personalised treatment. The model comprises six differential equations describing cancer cell...
Predicting animal movements and spatial distributions is crucial for our comprehension of ecological processes and provides key evidence for conserving and managing populations, species and ecosystems. Notwithstanding considerable progress in movemen...
This study presents a new design for a multi-degree-of-freedom underdriven mechanism. The aim is to achieve efficient bionic motion of a sea turtle hydrofoil with multi-degrees-of-freedom using a single drive source. The design focuses on the kinemat...
British journal of clinical pharmacology
Apr 3, 2025
AIMS: The uncertainty about the efficacy and safety of currently used azithromycin dosing regimens in children warrants individualized therapy. The area under the plasma concentration-time curve over 24 h (AUC) of azithromycin correlates best with it...
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Apr 2, 2025
Many mathematical models suffer from model discrepancy, posing a significant challenge to their use in clinical decision-making. In this article, we consider methods for addressing this issue. In the first approach, a mathematical model is treated as...
A framework for parameter estimation and uncertainty quantification is crucial for understanding the mechanisms of biological interactions within complex systems and exploring their dynamic behaviors beyond what can be experimentally observed. Despit...
Accurate prediction of new compounds' pharmacokinetic (PK) profile in humans is crucial for drug discovery. Traditional methods, including allometric scaling and mechanistic modeling, rely on parameters from or testing, which are labor-intensive an...
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