Background and purpose - External validation of machine learning (ML) prediction models is an essential step before clinical application. We assessed the proportion, performance, and transparent reporting of externally validated ML prediction models ...
IEEE transactions on visualization and computer graphics
Apr 15, 2021
Human visual attention in immersive virtual reality (VR) is key for many important applications, such as content design, gaze-contingent rendering, or gaze-based interaction. However, prior works typically focused on free-viewing conditions that have...
A key challenge to gaining insight into complex systems is inferring nonlinear causal directional relations from observational time-series data. Specifically, estimating causal relationships between interacting components in large systems with only s...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 8, 2021
There is often a limited amount of omics data to design predictive models in biomedicine. Knowing that these omics data come from underlying processes that may share common pathways and disease mechanisms, it may be beneficial for designing a more ac...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 6, 2021
Computational drug repositioning, which is an efficient approach to find potential indications for drugs, has been used to increase the efficiency of drug development. The drug repositioning problem essentially is a top-K recommendation task that rec...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 6, 2021
High-throughput screening technologies have provided a large amount of drug sensitivity data for a panel of cancer cell lines and hundreds of compounds. Computational approaches to analyzing these data can benefit anticancer therapeutics by identifyi...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 6, 2021
Protein phosphorylation is one of the key mechanism in prokaryotes and eukaryotes and is responsible for various biological functions such as protein degradation, intracellular localization, the multitude of cellular processes, molecular association,...
Reproductive biology and endocrinology : RB&E
Apr 5, 2021
BACKGROUND: To minimize the rate of in vitro fertilization (IVF)- associated multiple-embryo gestation, significant efforts have been made. Previous studies related to machine learning in IVF mainly focused on selecting the top-quality embryos to imp...
Computer methods and programs in biomedicine
Apr 1, 2021
BACKGROUND AND OBJECTIVE: an accurate estimation of the epidemiological model coefficients helps understand the basic principles of disease spreading. Some studies showed that dozens of hours are needed to simulate the traditional probabilistic cellu...
The human microbiome is increasingly mined for diagnostic and therapeutic biomarkers using machine learning (ML). However, metagenomics-specific software is scarce, and overoptimistic evaluation and limited cross-study generalization are prevailing i...