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Multiple Sclerosis

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Integrating Clinical Data and Patient-Reported Outcomes for Analyzing Gender Differences and Progression in Multiple Sclerosis Using Machine Learning.

Studies in health technology and informatics
Multiple sclerosis (MS) is a complex neurodegenerative disease with a variable prognosis that complicates effective management and treatment. This study leverages machine learning (ML) to enhance the understanding of disease progression and uncover g...

Structural-based uncertainty in deep learning across anatomical scales: Analysis in white matter lesion segmentation.

Computers in biology and medicine
This paper explores uncertainty quantification (UQ) as an indicator of the trustworthiness of automated deep-learning (DL) tools in the context of white matter lesion (WML) segmentation from magnetic resonance imaging (MRI) scans of multiple sclerosi...

Automated assessment of brain MRIs in multiple sclerosis patients significantly reduces reading time.

Neuroradiology
INTRODUCTION: Assessment of multiple sclerosis (MS) lesions on magnetic resonance imaging (MRI) is tedious, time-consuming, and error-prone. We evaluate whether assessment of new, expanding, and contrast-enhancing MS lesions can be done more time-eff...

A density-based MS disease diagnosis model using the capuchin search algorithm and an ensemble of deep neural networks.

Scientific reports
Multiple sclerosis (MS) is a severe brain disease that permanently destroys brain cells, impacting vision, balance, muscle control, and daily activity. This research employs a weighted combination of deep neural networks and optimization techniques f...

Enhancing classification of active and non-active lesions in multiple sclerosis: machine learning models and feature selection techniques.

BMC medical imaging
INTRODUCTION: Gadolinium-based T1-weighted MRI sequence is the gold standard for the detection of active multiple sclerosis (MS) lesions. The performance of machine learning (ML) and deep learning (DL) models in the classification of active and non-a...

Deep Learning techniques to detect and analysis of multiple sclerosis through MRI: A systematic literature review.

Computers in biology and medicine
Deep learning (DL) techniques represent a rapidly advancing field within artificial intelligence, gaining significant prominence in the detection and analysis of various medical conditions through the analysis of medical data. This study presents a s...

Identification of lipid metabolism-related gene markers and construction of a diagnostic model for multiple sclerosis: An integrated analysis by bioinformatics and machine learning.

Analytical biochemistry
BACKGROUND: Multiple sclerosis (MS) is an autoimmune inflammatory disorder that causes neurological disability. Dysregulated lipid metabolism contributes to the pathogenesis of MS. This study aimed to identify lipid metabolism-related gene markers an...

AI-based assessment of longitudinal multiple sclerosis MRI: Strengths and weaknesses in clinical practice.

European journal of radiology
OBJECTIVES: In Multiple Sclerosis (MS) cerebral MRI is essential for disease and treatment monitoring. For this purpose, software solutions are available to support the radiologist with image interpretation and reporting of follow up imaging. Aim of ...

Differentiation between multiple sclerosis and neuromyelitis optic spectrum disorders with multilevel fMRI features: A machine learning analysis.

Scientific reports
The conventional statistical approach for analyzing resting state functional MRI (rs-fMRI) data struggles to accurately distinguish between patients with multiple sclerosis (MS) and those with neuromyelitis optic spectrum disorders (NMOSD), highlight...

Deep learning-based prediction of autoimmune diseases.

Scientific reports
Autoimmune Diseases are a complex group of diseases caused by the immune system mistakenly attacking body tissues. Their etiology involves multiple factors such as genetics, environmental factors, and abnormalities in immune cells, making prediction ...