Alzheimer's & dementia : the journal of the Alzheimer's Association
Jun 11, 2019
INTRODUCTION: It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer's disease (AD) dementia.
Machine learning is increasingly being applied to neuroimaging data. However, most machine learning algorithms have not been designed to accommodate neuroimaging data, which typically has many more data points than subjects, in addition to multicolli...
Longitudinal imaging biomarkers are invaluable for understanding the course of neurodegeneration, promising the ability to track disease progression and to detect disease earlier than cross-sectional biomarkers. To properly realize their potential, b...
AJNR. American journal of neuroradiology
May 30, 2019
BACKGROUND AND PURPOSE: Accurate automated infarct segmentation is needed for acute ischemic stroke studies relying on infarct volumes as an imaging phenotype or biomarker that require large numbers of subjects. This study investigated whether an ens...
AJNR. American journal of neuroradiology
May 30, 2019
BACKGROUND AND PURPOSE: 3D reconstruction of a targeted area ("safe" triangle and Kambin triangle) may benefit the viability assessment of transforaminal epidural steroid injection, especially at the L5/S1 level. However, manual segmentation of lumbo...
RATIONALE: The impact of neuroscience-based approaches for psychiatry on pragmatic clinical decision-making has been limited. Although neuroscience has provided insights into basic mechanisms of neural function, these insights have not improved the a...
BACKGROUND: Hippocampus is one of the first structures affected by neurodegenerative diseases such as Alzheimer's disease (AD) and mild cognitive impairment (MCI). Hippocampal atrophy can be evaluated in terms of hippocampal volumes and shapes using ...
Quantifying the degree of atrophy is done clinically by neuroradiologists following established visual rating scales. For these assessments to be reliable the rater requires substantial training and experience, and even then the rating agreement betw...
With the advent of convolutional neural networks (CNN), supervised learning methods are increasingly being used for whole brain segmentation. However, a large, manually annotated training dataset of labeled brain images required to train such supervi...
Parkinson's disease (PD) is a common neurodegenerative disorder. It has a delitescent onset and a slow progress. The clinical manifestations of PD in patients are highly heterogeneous. Thus, PD diagnosis process is complex and mainly depends on the p...