INTRODUCTION AND HYPOTHESIS: The use of synthetic mesh in transvaginal pelvic floor surgery has been subject to debate internationally. Although mesh erosion appears to be less associated with an abdominal approach, the long-term outcome has not been...
Clinical trials have identified a variety of predictor variables for use in precision treatment protocols, ranging from clinical biomarkers and symptom profiles to self-report measures of various sorts. Although such variables are informative collect...
Biometrical journal. Biometrische Zeitschrift
May 14, 2019
Propensity score matching (PSM) and propensity score weighting (PSW) are popular tools to estimate causal effects in observational studies. We address two open issues: how to estimate propensity scores and assess covariate balance. Using simulations,...
The international journal of biostatistics
Apr 16, 2019
We consider causal inference in observational studies with choice-based sampling, in which subject enrollment is stratified on treatment choice. Choice-based sampling has been considered mainly in the econometrics literature, but it can be useful for...
Machine learning is now being increasingly employed in radiology to assist with tasks such as automatic lesion detection, segmentation, and characterisation. We are currently involved in an National Institute of Health Research (NIHR)-funded project,...
Journal of evaluation in clinical practice
Mar 28, 2017
RATIONALE, AIMS AND OBJECTIVES: In evaluating non-randomized interventions, propensity scores (PS) estimate the probability of assignment to the treatment group given observed characteristics. Machine learning algorithms have been proposed as an alte...
Estimation of causal effects using observational data continues to grow in popularity in the epidemiologic literature. While many applications of causal effect estimation use propensity score methods or G-computation, targeted maximum likelihood esti...
Journal of evaluation in clinical practice
Mar 23, 2016
In order to assess the effectiveness of matching approaches in observational studies, investigators typically present summary statistics for each observed pre-intervention covariate, with the objective of showing that matching reduces the difference ...
Nutrition (Burbank, Los Angeles County, Calif.)
Dec 22, 2015
OBJECTIVES: Inconsistent findings have been published regarding vitamin D status among patients with Crohn's disease (CD) and the association with disease severity. We aimed to perform a meta-analysis evaluating serum 25-hydroxy vitamin D and 1,25 de...
BACKGROUND: Despite advances in pain management, inadequate pain relief and opioid-related adverse events remain common challenges in perioperative care, often contributing to prolonged recovery and reduced quality of life. The perioperative opioid a...
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